Integration of androgen hormones in endometrial cancer biology

Gjorgoska, Marija (author), Lanišnik-Rižner, Tea (author)

Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In recent years, genomic studies revealed continually evolving mutational landscapes of endometrial tumors that hold great potential for tailoring therapeutic strategies. This review aims to broaden our knowledge of EC biology by focusing on the role of androgen hormones. First, we discuss epidemiological evidence implicating androgens with EC pathogenesis and cover their biosynthesis and metabolism to bioactive 11-oxyandrogens. Next, we explore the endometrial tumor tissue and the altered microbiota as alternative sources of androgens and their 11-oxymetabolites in EC patients. Finally, we discuss the biological significance of androgens' genomic and nongenomic signaling as part of a medley of pathways ultimately deciding the fate of cells.

• Language: English
• Keywords: endocrinology, endometrial cancer, androgen hormones, androgen receptor, androgens, androgen signaling, molecular targeted therapy, 11-oxyandrogens
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2022
• Number of pages: Str. 639-651
• Numbering: Vol. 33, no. 9
• PID: 20.500.12556/RUL-145191
• UDC: 618.1
• ISSN on article: 1043-2760
• DOI: 10.1016/j.tem.2022.06.001
• COBISS.SI-ID: 116172547
• Publication date in RUL: 13.04.2023

Record is a part of a journal

• Title: Trends in endocrinology and metabolism
• Shortened title: Trends endocrinol. metab.
• Publisher: Elsevier
• ISSN: 1043-2760
• COBISS.SI-ID: 1191188

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: endokrinologija, rak endometrija, androgeni hormoni

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: J3-2535
• Name: Vloga androgenov pri hormonsko odvisnih boleznih: pomen za diagnostiko in zdravljenje