Urine and Fecal $^1$H-NMR metabolomes differ significantly between pre-term and full-term born physically fit healthy adult males

Deutsch, Leon (avtor), Debevec, Tadej (avtor), Millet, Grégoire P. (avtor), Osredkar, Damjan (avtor), Opara, Simona (avtor), Šket, Robert (avtor), Murovec, Boštjan (avtor), Mramor, Minca (avtor), Plavec, Janez (avtor), Stres, Blaž (avtor)

Preterm birth (before 37 weeks gestation) accounts for ~10% of births worldwide and remains one of the leading causes of death in children under 5 years of age. Preterm born adults have been consistently shown to be at an increased risk for chronic disorders including cardiovascular, endocrine/metabolic, respiratory, renal, neurologic, and psychiatric disorders that result in increased death risk. Oxidative stress was shown to be an important risk factor for hypertension, metabolic syndrome and lung disease (reduced pulmonary function, long-term obstructive pulmonary disease, respiratory infections, and sleep disturbances). The aim of this study was to explore the differences between preterm and full-term male participants’ levels of urine and fecal proton nuclear magnetic resonance ($^1$H-NMR) metabolomes, during rest and exercise in normoxia and hypoxia and to assess general differences in human gut-microbiomes through metagenomics at the level of taxonomy, diversity, functional genes, enzymatic reactions, metabolic pathways and predicted gut metabolites. Significant differences existed between the two groups based on the analysis of $^1$H-NMR urine and fecal metabolomes and their respective metabolic pathways, enabling the elucidation of a complex set of microbiome related metabolic biomarkers, supporting the idea of distinct host-microbiome interactions between the two groups and enabling the efficient classification of samples; however, this could not be directed to specific taxonomic characteristics.

• Jezik: Angleški jezik
• Ključne besede: premature birth, $^1$H-NMR metabolomics, hypoxia, fecal metagenomics, biomarkers, activity, hypoxia
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: BF - Biotehniška fakulteta ; FŠ - Fakulteta za šport ; MF - Medicinska fakulteta ; FE - Fakulteta za elektrotehniko; FGG - Fakulteta za gradbeništvo in geodezijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2022
• Št. strani: 22 str.
• Številčenje: Vol. 12, iss. 6, art. 536
• PID: 20.500.12556/RUL-138367
• UDK: 612
• ISSN pri članku: 2218-1989
• DOI: 10.3390/metabo12060536
• COBISS.SI-ID: 111333123
• Datum objave v RUL: 18.07.2022

Gradivo je del revije

• Naslov: Metabolites
• Skrajšan naslov: Metabolites
• Založnik: MDPI
• ISSN: 2218-1989
• COBISS.SI-ID: 523274009

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Angleški jezik
• Ključne besede: biokemija, metabolomika, prezgodnje rojstvo, odrasli moški, biomarkerji