Sex-related differences in cardiovascular disease risk profile in children and adolescents with type 1 diabetes

Šmigoc Schweiger, Darja (avtor), Battelino, Tadej (avtor), Grošelj, Urh (avtor)

Cardiovascular disease (CVD) is the primary cause of higher and earlier morbidity and mortality in people with type 1 diabetes (T1D) compared to people without diabetes. In addition, women with T1D are at an even higher relative risk for CVD than men. However, the underlying pathophysiology is not well understood. Atherosclerotic changes are known to progress early in life among people with T1D, yet it is less clear when excess CVD risk begins in females with T1D. This review explores the prevalence of classical CVD risk factors (such as glycemic control, hypertension, dyslipidemia, obesity, albuminuria, smoking, diet, physical inactivity), as well as of novel biomarkers (such as chronic inflammation), in children and adolescents with T1D with particular regard to sex-related differences in risk profile. We also summarize gaps where further research and clearer clinical guidance are needed to better address this issue. Considering that girls with T1D might have a more adverse CVD risk profile than boys, the early identification of and sex-specific intervention in T1D would have the potential to reduce later CVD morbidity and excess mortality in females with T1D. To conclude, based on an extensive review of the existing literature, we found a clear difference between boys and girls with T1D in the presence of individual CVD risk factors as well as in overall CVD risk profiles; the girls were on the whole more impacted.

• Jezik: Angleški jezik
• Ključne besede: sex, gender, cardiovascular risk factors, type 1 diabetes, children, adolescents, blood pressure, hyperglycemia, dyslipidemia, inflammation, smoking
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2021
• Št. strani: 29 str.
• Številčenje: Vol. 22, iss. 19, art. 10192
• PID: 20.500.12556/RUL-136338
• UDK: 616.379
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms221910192
• COBISS.SI-ID: 77665795
• Datum objave v RUL: 25.04.2022

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 01.10.2021

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: spol, tveganje za srčno-žilna obolenja, sladkorna bolezen tipa 1, otroci, mladostniki, krvni tlak, hiperglikemija, dislipidemija, kajenje, infekcijske bolezni

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0343
• Naslov: Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J3-2536
• Naslov: Ugotavljanje genetskih vzrokov dislipidemij pri otrocih in mladostnikih ter njihovo zgodnje odkrivanje s populacijskim presejanjem