Erythropoietin and its angiogenic activity

Kimáková, Patrícia (avtor), Solár, Peter (avtor), Solárová, Zuzana (avtor), Komel, Radovan (avtor), Debeljak, Nataša (avtor)

Erythropoietin (EPO) is the main hematopoietic hormone acting on progenitor red blood cells via stimulation of cell growth, differentiation, and anti-apoptosis. However, its receptor (EPOR) is also expressed in various non-hematopoietic tissues, including endothelium. EPO is a pleiotropic growth factor that exhibits growth stimulation and cell/tissue protection on numerous cells and tissues. In this article we review the angiogenesis potential of EPO on endothelial cells in heart, brain, and leg ischemia, as well as its role in retinopathy protection and tumor promotion. Furthermore, the effect of EPO on bone marrow and adipose tissue is also discussed.

• Jezik: Angleški jezik
• Ključne besede: erythropoietin, erythropoietin receptor, cancer, endothelial, angiogenesis
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2017
• Št. strani: 14 str.
• Številčenje: Vol. 18, iss. 7, art. 1519
• PID: 20.500.12556/RUL-131076
• UDK: 616-006
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms18071519
• COBISS.SI-ID: 33325785
• Datum objave v RUL: 22.09.2021

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 13.07.2017

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: eritropoetin, receptor eritropoetina, rak

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: Ministry of Education of the Slovak
• Številka projekta: VEGA 1/0394/15