Erythropoietin and its angiogenic activity

Kimáková, Patrícia (author), Solár, Peter (author), Solárová, Zuzana (author), Komel, Radovan (author), Debeljak, Nataša (author)

Erythropoietin (EPO) is the main hematopoietic hormone acting on progenitor red blood cells via stimulation of cell growth, differentiation, and anti-apoptosis. However, its receptor (EPOR) is also expressed in various non-hematopoietic tissues, including endothelium. EPO is a pleiotropic growth factor that exhibits growth stimulation and cell/tissue protection on numerous cells and tissues. In this article we review the angiogenesis potential of EPO on endothelial cells in heart, brain, and leg ischemia, as well as its role in retinopathy protection and tumor promotion. Furthermore, the effect of EPO on bone marrow and adipose tissue is also discussed.

• Language: English
• Keywords: erythropoietin, erythropoietin receptor, cancer, endothelial, angiogenesis
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2017
• Number of pages: 14 str.
• Numbering: Vol. 18, iss. 7, art. 1519
• PID: 20.500.12556/RUL-131076
• UDC: 616-006
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms18071519
• COBISS.SI-ID: 33325785
• Publication date in RUL: 22.09.2021

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Licensing start date: 13.07.2017

Secondary language

• Language: Slovenian
• Keywords: eritropoetin, receptor eritropoetina, rak

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: Ministry of Education of the Slovak
• Project number: VEGA 1/0394/15