Uromodulin and microRNAs in kidney transplantation - association with kidney graft function

Borštnar, Špela (avtor), Večerić-Haler, Željka (avtor), Boštjančič, Emanuela (avtor), Pipan Tkalec, Živa (avtor), Kovač, Damjan (avtor), Lindič, Jelka (avtor), Kojc, Nika (avtor)

Uromodulin and microRNAs (miRNAs) have recently been investigated as potential biomarkers for kidney graft associated pathology and outcome, with a special focus on biomarkers indicating specific disease processes and kidney graft survival. The study's aim was to determine whether expression of serum uromodulin concentration and selected miRNAs might be related to renal function in kidney transplant recipients (KTRs). The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. Kidney graft function was estimated with routine parameters (creatinine, urea, cystatin C, and Chronic Kidney Disease Epidemiology Collaboration study equations) and precisely measured using chromium-51 labelled ethylenediaminetetraacetic-acid clearance. The selected miRNAs were shown to be independent of kidney graft function, indicating their potential as biomarkers of associated kidney graft disease processes. In contrast, the serum uromodulin level depended entirely on kidney graft function and thus reflected functioning tubules rather than any specific kidney graft injury. However, decreased concentrations of serum uromodulin can be observed in the early course of tubulo interstitial injury, there by suggesting its useful role as an accurate, noninvasive biomarker of early (subclinical) kidney graft injury.

• Jezik: Angleški jezik
• Ključne besede: microRNA, uromodulin, kidney graft function, biomarker, kidney transplantation
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2020
• Št. strani: 11 str.
• Številčenje: Vol. 21, iss. 16, art. 5592
• PID: 20.500.12556/RUL-128786
• UDK: 616.6
• ISSN pri članku: 1422-0067
• DOI: 10.3390/ijms21165592
• COBISS.SI-ID: 24550915
• Datum objave v RUL: 29.07.2021

Gradivo je del revije

• Naslov: International journal of molecular sciences
• Skrajšan naslov: Int. j. mol. sci.
• Založnik: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
• Začetek licenciranja: 05.08.2020

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: mikroRNA, uromodulin, delovanje ledvičnega presadka, biološki označevalec, presaditev ledvic

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0323
• Naslov: Ledvične bolezni in nadomestna zdravljenja

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0054
• Naslov: Patologija in molekularna genetika