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Uromodulin and microRNAs in kidney transplantation - association with kidney graft function
ID Borštnar, Špela (Author), ID Večerić-Haler, Željka (Author), ID Boštjančič, Emanuela (Author), ID Pipan Tkalec, Živa (Author), ID Kovač, Damjan (Author), ID Lindič, Jelka (Author), ID Kojc, Nika (Author)

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Abstract
Uromodulin and microRNAs (miRNAs) have recently been investigated as potential biomarkers for kidney graft associated pathology and outcome, with a special focus on biomarkers indicating specific disease processes and kidney graft survival. The study's aim was to determine whether expression of serum uromodulin concentration and selected miRNAs might be related to renal function in kidney transplant recipients (KTRs). The uromodulin concentration and expression of six selected miRNAs (miR-29c, miR-126, miR-146a, miR-150, miR-155, and miR-223) were determined in the serum of 100 KTRs with stable graft function and chronic kidney disease of all five stages. Kidney graft function was estimated with routine parameters (creatinine, urea, cystatin C, and Chronic Kidney Disease Epidemiology Collaboration study equations) and precisely measured using chromium-51 labelled ethylenediaminetetraacetic-acid clearance. The selected miRNAs were shown to be independent of kidney graft function, indicating their potential as biomarkers of associated kidney graft disease processes. In contrast, the serum uromodulin level depended entirely on kidney graft function and thus reflected functioning tubules rather than any specific kidney graft injury. However, decreased concentrations of serum uromodulin can be observed in the early course of tubulo interstitial injury, there by suggesting its useful role as an accurate, noninvasive biomarker of early (subclinical) kidney graft injury.

Language:English
Keywords:microRNA, uromodulin, kidney graft function, biomarker, kidney transplantation
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2020
Number of pages:11 str.
Numbering:Vol. 21, iss. 16, art. 5592
PID:20.500.12556/RUL-128786 This link opens in a new window
UDC:616.6
ISSN on article:1422-0067
DOI:10.3390/ijms21165592 This link opens in a new window
COBISS.SI-ID:24550915 This link opens in a new window
Publication date in RUL:29.07.2021
Views:1030
Downloads:165
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Record is a part of a journal

Title:International journal of molecular sciences
Shortened title:Int. j. mol. sci.
Publisher:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:05.08.2020

Secondary language

Language:Slovenian
Keywords:mikroRNA, uromodulin, delovanje ledvičnega presadka, biološki označevalec, presaditev ledvic

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P3-0323
Name:Ledvične bolezni in nadomestna zdravljenja

Funder:ARRS - Slovenian Research Agency
Project number:P3-0054
Name:Patologija in molekularna genetika

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