Vaš brskalnik ne omogoča JavaScript!
JavaScript je nujen za pravilno delovanje teh spletnih strani. Omogočite JavaScript ali pa uporabite sodobnejši brskalnik.
Nacionalni portal odprte znanosti
Odprta znanost
DiKUL
slv
|
eng
Iskanje
Brskanje
Novo v RUL
Kaj je RUL
V številkah
Pomoč
Prijava
Po članicah UL
Deleži
Največkrat
Datoteke
Letna poročila
Mentorstva
Osnovno
Bibliografija
Objave zaključnih del
Top ključne besede
Pojavnost ključnih besed
Komentorji
Bibliografija osebe. Seznam zajema vsa gradiva in ne le tista, kje je oseba mentor.
Magistrska dela (5)
Damijan Knez:
Sinteza novih cianotiofenskih zaviralcev bakterijskega encima MurF
Matej Strelec:
Sinteza in vrednotenje potencialnih zaviralcev ligaz DdlB in MurF na osnovi monobaktamskega skeleta
Samo Kuzmič:
Načrtovanje, sinteza in vrednotenje mimetikov D-Ala-D-Ala z azidinskim gradnikom
Janja Ahej:
Uvedba bioizosternih zamenjav za fenilno skupino na mestu 1 pri 1,2,3,4-tetrahidropirolo[1,2-a]pirazinskem tipu zaviralcev InhA
Marko Ključevšek:
Razvoj sintezne poti za pripravo 4-hidroksifenilglicinskih derivatov monobaktamov
Diplomska dela (2)
Snežana Podričnik:
Cianotiofenski zaviralci ligaze MurF kot potencialne protibakterijske učinkovine
Uroš Mesec:
Iskanje novih potencialnih zaviralcev N-acetilglukozamin enolpiruvil tranferaze z rešetanjem knjižnice spojin Fakultete za farmacijo
Druga dela (23)
Valentina Straniero, Lorenzo Suigo, Andrea Casiraghi, Victor Sebastián-Pérez, Martina Hrast, Carlo Zanotto, Irena Zdovc, Carlo De Giuli Morghen, Antonia Radaelli, Ermanno Valoti:
Benzamide derivatives targeting the cell division protein FtsZ
Janez Mravljak, Lara Slavec, Martina Hrast, Matej Sova:
Synthesis and evaluation of antioxidant properties of 2-substituted quinazolin-4(3H)-ones
Maja Kokot, Matjaž Weiss, Irena Zdovc, Lidija Senerovic, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast:
Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy
Macarena Funes Chabán, Martina Hrast, Rok Frlan, Dafni G. Graikioti, Constantinos M. Athanassopoulos, María Cecilia Carpinella:
Inhibition of MurA enzyme from Escherichia coli and Staphylococcus aureus by diterpenes from Lepechinia meyenii and their synthetic analogs
Anja Kolarič, Thomas Germe, Martina Hrast, Clare E. M. Stevenson, David M. Lawson, Nicolas P. Burton, Judit Vörös, Anthony Maxwell, Nikola Minovski, Marko Anderluh:
Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds
Janja Sluga, Tihomir Tomašič, Marko Anderluh, Martina Hrast, Gregor Bajc, Alen Sevšek, Nathaniel I. Martin, Roland J. Pieters, Marjana Novič, Katja Venko:
Targeting N-acetylglucosaminidase in Staphylococcus aureus with iminosugar inhibitors
Matic Proj, Krištof Bozovičar, Martina Hrast, Rok Frlan, Stanislav Gobec:
DNA-encoded library screening on two validated enzymes of the peptidoglycan biosynthetic pathway
David J. Hamilton, Péter Ábrányi-Balogh, Aaron Keeley, László Petri, Martina Hrast, Tímea Imre, Maikel Wijtmans, Stanislav Gobec, Iwan J. P. de Esch, György Keserü M.:
Bromo-cyclobutenaminones as new covalent UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) inhibitors
Nace Zidar, Alessia Onali, Peter Peršolja, Davide Benedetto Tiz, Jaka Dernovšek, Žiga Skok, Martina Durcik, Andrej Emanuel Cotman, Martina Hrast, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašič, Danijel Kikelj:
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains
Rok Frlan, Martina Hrast, Stanislav Gobec:
Application of the N-dibenzyl protective group in the preparation of β-lactam pseudopeptides
Valentina Straniero, Victor Sebastián-Pérez, Lorenzo Suigo, William Margolin, Andrea Casiraghi, Martina Hrast, Carlo Zanotto, Irena Zdovc, Antonia Radaelli, Ermanno Valoti:
Computational design and development of benzodioxane-benzamides as potent inhibitors of FtsZ by exploring the hydrophobic subpocket
Damijan Knez, Stanislav Gobec, Martina Hrast:
Screening of big pharma’s library against various in-house biological targets
Anja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski:
A fine-tuned lipophilicity/hydrophilicity ratio governs antibacterial potency and selectivity of bifurcated halogen bond-forming NBTIs
Maja Kokot, Marko Anderluh, Martina Hrast, Nikola Minovski:
The structural features of novel bacterial topoisomerase inhibitors that define their activity on topoisomerase IV
Katarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György Keserü M., Stanislav Gobec:
Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead
Maja Kokot, Matjaž Weiss, Irena Zdovc, Martina Hrast, Marko Anderluh, Nikola Minovski:
Structurally optimized potent dual-targeting NBTI antibacterials with an enhanced bifurcated halogen-bonding propensity
Samo Kuzmič, Martina Hrast, Rok Frlan:
The synthesis of (2R)-aziridine-2-carboxylic acid containing dipeptides
Péter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György Keserü M.:
Next-generation heterocyclic electrophiles as small-molecule covalent MurA inhibitors
Matic Proj, Martina Hrast, Gregor Bajc, Rok Frlan, Anže Meden, Matej Butala, Stanislav Gobec:
Discovery of a fragment hit compound targeting D-Ala:D-Ala ligase of bacterial peptidoglycan biosynthesis
Matic Proj, Martina Hrast, Damijan Knez, Krištof Bozovičar, Katarina Grabrijan, Anže Meden, Stanislav Gobec, Rok Frlan:
Fragment-sized thiazoles in fragment-based drug discovery campaigns
Martina Hrast, Irena Zdovc, Nina Kočevar Glavač, Stanislav Gobec, Rok Frlan:
Mur ligase F as a new target for the flavonoids quercitrin, myricetin, and (–)-epicatechin
Maja Kokot, Doroteja Novak, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski:
Exploring alternative pathways to target bacterial type II topoisomerases using NBTI antibacterials: beyond halogen-bonding interactions
Rok Frlan, Martina Hrast, Stanislav Gobec:
Inhibition of MurA enzyme from Escherichia coli by flavonoids and their synthetic analogues