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PhD theses (4)
Andraž Lamut:
Načrtovanje in sinteza novih protimikrobno delujočih zaviralcev DNA-giraze in Hsp90
Marina Gjorgjieva:
Design, synthesis and evaluation of DNA gyrase B inhibitors based on the benzothiazole scaffold
Rok Martinčič:
Napovedovanje antioksidativne aktivnosti in transmembranskega transporta derivatov pulvinske kisline in kumarina
Davide Benedetto Tiz:
Razvoj novih N-fenilpirolamidov kot zaviralcev DNA-giraze in topoizomeraze IV
MSc theses (8)
Marko Trampuž:
Načrtovanje in sinteza aminokislinskih derivatov substituiranih pirolamidov kot zaviralcev bakterijske DNA giraze B
Kristina Nemec:
Sinteza derivatov 4-amino-1H-pirol-2-karboksamida s potencialnim zaviralnim delovanjem na girazo B
Jure Požar:
Sinteza potencialnih zaviralcev giraze B z 1,4-benzoksazinskim skeletom
Andreja Jernej:
Načrtovanje in sinteza potencialnih zaviralcev giraze B z aminoetanolnim fragmentom
Lea Sajovic:
Sinteza potencialnih tetrahidrokinazolinskih zaviralcev DNA giraze B
Andrej Emanuel Cotman:
Načrtovanje in sinteza analogov 4,5-dibromo-1H-pirola s tirozinskim fragmentom kot zaviralcev giraze B s protibakterijskim delovanjem
Eva Jerič:
Načrtovanje in sinteza derivatov 3-amino-2-tioksitiazoldin-4-ona in 1H-pirol-3-amina kot potencialnih zaviralcev giraze B
Jure Požar:
Sinteza potencialnih zaviralcev giraze B z 1,4-benzoksazinskim skeletom
BSc theses (7)
Jernej Grmaš:
Razvoj metod HPLC in MS za vrendotenje stabilnosti farmacevtskega pripravka
Uroš Trstenjak:
Načrtovanje in sinteza gradnikov novih inhibitorjev faktorja Xa
Žiga Hodnik:
Priprava in karakterizacija kokristalov flukonazola
Karlo Lovrić:
Vrednotenje kokristalov flukonazola, pripravljenih z mletjem
Saša Ciglič:
Sinteza derivatov benzo[b][1,4]dioksina in benzo[b][1,4]oksazina kot gradnikov dualnih antitrombotičnih učinkovin
Dominik Nabergoj:
Vrednotenje protivnetnega in proapoptotičnega delovanja sinteznih analogov klatrodina na humanih monocitnih levkemičnih celicah THP-1
Adrijana Krope:
Testiranje občutljivosti bakterij na nove potencialne inhibitorje Mur encimov
Other documents (22)
Steve Peigneur, Aleš Žula, Nace Zidar, Fiona Chan-Porter, Robert Kirby, David J. Madge, Janez Ilaš, Danijel Kikelj, Jan Tytgat:
Action of clathrodin and analogues on voltage-gated sodium channels
Nace Zidar, Sofia Montalvão, Žiga Hodnik, Dorota A. Nawrot, Aleš Žula, Janez Ilaš, Danijel Kikelj, Päivi Tammela, Lucija Peterlin-Mašič:
Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues
Žiga Jakopin, Janez Ilaš, Michaela Barančokova, Matjaž Brvar, Päivi Tammela, Marija Sollner Dolenc, Tihomir Tomašič, Danijel Kikelj:
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors
Polya G. Roydeva, Anna-Madeleine Beckmann, Marit Stirnberg, Jožko Cesar, Danijel Kikelj, Janez Ilaš, Michael Gütschow:
3,1-Benzothiazines, 1,4-benzodioxines, 1,4-benzoxazines as inhibitors of matriptase-2
Tihomir Tomašič, Matic Mirt, Michaela Barančokova, Janez Ilaš, Nace Zidar, Päivi Tammela, Danijel Kikelj:
Design, synthesis and biological evaluation of 4,5-dibromo-N-(thiazol-2-yl)-1H-pyrrole-2-carboxamide derivatives as novel DNA gyrase inhibitors
Martina Durcik, Päivi Tammela, Michaela Barančokova, Tihomir Tomašič, Janez Ilaš, Danijel Kikelj, Nace Zidar:
Synthesis and evaluation of N-phenylpyrrolamides as DNA gyrase B inhibitors
Martina Durcik, Andrej Emanuel Cotman, Žan Toplak, Štefan Možina, Žiga Skok, Maria Vittoria Piras, Nace Zidar, Janez Ilaš, Anamarija Zega, Jurij Trontelj, Danijel Kikelj, Tihomir Tomašič, Lucija Peterlin-Mašič:
New dual inhibitors of bacterial topoisomerases with broad-spectrum antibacterial activity and in vivo efficacy against vancomycin-intermediate Staphylococcus aureus
Aleš Žula, Izabela Będziak, Danijel Kikelj, Janez Ilaš:
Synthesis and evaluation of spumigin analogues library with thrombin inhibitory activity
Žiga Skok, Martina Durcik, Živa Zajec, Darja Gramec, Krištof Bozovičar, Anja Pišlar, Tihomir Tomašič, Anamarija Zega, Lucija Peterlin-Mašič, Danijel Kikelj, Nace Zidar, Janez Ilaš:
ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold
Michaela Barančokova, Danijel Kikelj, Janez Ilaš:
Recent progress in the discovery and development of DNA gyrase B inhibitors
Martina Durcik, Žiga Skok, Janez Ilaš, Nace Zidar, Anamarija Zega, Petra Szili, Gábor Draskovits, T. Revesz, Danijel Kikelj, Ákos Nyerges, Csaba Pál, Lucija Peterlin-Mašič, Tihomir Tomašič:
Hybrid inhibitors of DNA gyrase A and B
Nace Zidar, Alessia Onali, Peter Peršolja, Davide Benedetto Tiz, Jaka Dernovšek, Žiga Skok, Martina Durcik, Andrej Emanuel Cotman, Martina Hrast, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašič, Danijel Kikelj:
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains
Marina Gjorgjieva, Tihomir Tomašič, Michaela Barančokova, Sotirios Katsamakas, Janez Ilaš, Päivi Tammela, Lucija Peterlin-Mašič, Danijel Kikelj:
Discovery of benzothiazole scaffold-based DNA gyrase B inhibitors
Nace Zidar, Daniela Secci, Tihomir Tomašič, Lucija Peterlin-Mašič, Danijel Kikelj, Daniele Passarella, Aida Nelly Garcia Argaez, Mariafrancesca Hyeraci, Lisa Via Dalla:
Synthesis, antiproliferative effect and topoisomerase II inhibitory activity of 3-methyl-2-phenyl-1H-indoles
Žiga Skok, Michaela Barančokova, Ondřej Benek, Cristina Durante Cruz, Päivi Tammela, Tihomir Tomašič, Nace Zidar, Lucija Peterlin-Mašič, Anamarija Zega, Danijel Kikelj, Janez Ilaš:
Exploring the chemical space of benzothiazole-based DNA gyrase B inhibitors
Martina Durcik, Žan Toplak, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lucija Peterlin-Mašič, Tihomir Tomašič:
Efficient synthesis of hydroxy-substituted 2-aminobenzo[d]thiazole-6-carboxylic acid derivatives as new building blocks in drug discovery
Ákos Nyerges, Tihomir Tomašič, Martina Durcik, T. Revesz, Petra Szili, Žiga Skok, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lucija Peterlin-Mašič:
Rational design of balanced dual-targeting antibiotics with limited resistance
Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz, Federica Fulgheri, Daniela Secci, Maša Sterle, Štefan Možina, Žiga Skok, Nace Zidar, Anamarija Zega, Janez Ilaš, Lucija Peterlin-Mašič, Tihomir Tomašič, Danijel Kikelj:
Discovery and hit-to-lead optimization of benzothiazole scaffold-based DNA gyrase inhibitors with potent activity against Acinetobacter baumannii and Pseudomonas aeruginosa
Nace Zidar, Tihomir Tomašič, Danijel Kikelj, Martina Durcik, Jan Tytgat, Steve Peigneur, Marc Rogers, Alexander Haworth, Robert W. Kirby:
New aryl and acylsulfonamides as state-dependent inhibitors of Na$_v$1.3 voltage-gated sodium channel
Maša Sterle, Martina Durcik, Danijel Kikelj, Nace Zidar, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašič, Andrej Emanuel Cotman, Anamarija Zega:
Exploring the 5-substituted 2-aminobenzothiazole-based DNA gyrase B inhibitors active against ESKAPE pathogens
Nace Zidar, Andrej Emanuel Cotman, Wessel Sinnige, Ondřej Benek, Michaela Barančokova, Anamarija Zega, Lucija Peterlin-Mašič, Tihomir Tomašič, Janez Ilaš, Ricardo D. Enriz, Danijel Kikelj:
Exploring the interaction of N-(benzothiazol-2-yl)pyrrolamide DNA gyrase inhibitors with the GyrB ATP-binding site lipophilic floor
Andrej Emanuel Cotman, Federica Fulgheri, Martina Piga, Peter Peršolja, Davide Benedetto Tiz, Žiga Skok, Martina Durcik, Maša Sterle, Jaka Dernovšek, Anamarija Zega, Lucija Peterlin-Mašič, Janez Ilaš, Tihomir Tomašič, Danijel Kikelj, Nace Zidar:
New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity