Peristaltični simulator s povečano zmogljivostjo

Zavrl, Blaž (author), Diaci, Janez (mentor)

Za namen izvajanja in-vitro testov sproščanja farmakoloških učinkovin je razvit nov peristaltični simulator z dvema nagibnima platformama ter štirimi cevmi. Predložena naloga obravnava snovanje nove naprave, analizo dinamike gibanja naprave in izbiro ustreznih mehatronskih komponent. V okviru naloge je bila razvita in izdelana namenska testna naprava, s katero je bila opravljena eksperimentalna optimizacija nastavitev krmilnikov motorjev in vizualna analiza gibanja tekočine znotraj testirnih cevi. Izpopolnjeno je programsko vodenje naprave, ki odpravlja izgubo sinhronizacije tekom delovanja in onemogoča akumulacijo napake pozicije. Nova naprava zagotavlja sočasno testiranje v štirih ceveh ter pri maksimalnih amplitudah nagibnih gibanj omogoča dvakrat krajše periode kot predhodna naprava tega tipa.

• Language: Slovenian
• Keywords: Peristaltika Simuliranje peristaltičnih gibanj Testiranje sproščanja učinkovin Snovanje peristaltičnega simulatorja Analiza nagibnih gibanj
• Work type: Master's thesis/paper
• Organization: FS - Faculty of Mechanical Engineering
• Year: 2017
• PID: 20.500.12556/RUL-95508
• Publication date in RUL: 20.09.2017

Secondary language

• Language: English
• Title: Peristaltic simulator with improved performance

Abstract

For the purpose of carrying out in-vitro drug release testing, we have developed a new peristaltic simulator with two tilt platforms and four peristaltic tubes. This thesis covers the design of the new simulator, an analysis of the machine’s motion dynamics and the selection of appropriate mechatronic components. As part of the thesis, a test version of the simulator was developed, which was used to carry out an experimentation-based optimization of motor driver settings as well as a visual analysis of fluid movement within the test tubes. The software controlling the simulator has been improved so that synchronisation issues no longer arise while the machine is operating and there is no more accumulation of position errors. The new simulator allows simultaneous testing in four tubes and can be run at periods that are twice shorter than in previously developed device of this type, while functioning at maximum amplitudes of tilting movement.

• Keywords: Peristaltics Simulation of peristaltic movements In-vitro drug release testing Peristaltic simulator design Analysis of tilting movements