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Uporaba bioloških omrežij za izračun funkcijske obogatenosti skupine genov
ID Cvitkovič, Robert (Author), ID Curk, Tomaž (Mentor) More about this mentor... This link opens in a new window

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MD5: 89CABA95DDA2F3A7E1D45C53ADBAF196
PID: 20.500.12556/rul/40c0a6b1-3f0d-47b0-9098-6e886f6ffd83

Abstract
Molekularni biologi in genetiki se dandanes ukvarjajo s proučevanjem zapisa DNA. Pri eksperimentih tipično dobijo podatke, ki se zaradi svoje narave težko interpretirajo. Klasične metode primerjajo eksperimentalno dobljeno skupino genov z znanimi, funkcijsko povezanimi skupinami genov, a pogosto niso uspešne. Izboljšava pristopa je metoda SANTA, ki vrednoti eksperimentalne rezultate na podlagi omrežja genov. Metodo SANTA smo implementirali v sklopu diplome, v dodatku Orange Bioinformatics. Orange je že dobro uveljavljen program za obdelavo podatkov. Dodatek Bioinformatics zavzema specializirane funkcionalnosti za obdelavo genskih podatkov. Dodatek smo obogatili tudi z izboljšanim dostopom do zbirk BioGRID in STRING, ki hranita podatke o eksperimentalno določenih povezavah med geni.

Language:Slovenian
Keywords:Python, Orange, bioinformatika, omrežje, SANTA, STRING, BioGRID
Work type:Bachelor thesis/paper
Organization:FRI - Faculty of Computer and Information Science
Year:2017
PID:20.500.12556/RUL-95069 This link opens in a new window
Publication date in RUL:13.09.2017
Views:1299
Downloads:342
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Secondary language

Language:English
Title:Gene set function enrichment analysis using biological networks
Abstract:
Molecular biologists and geneticists are, nowadays, mostly focused on studying and understanding the DNA transcription. The gathered experimental data is difficult to interpret. Classical methods compare the discovered groups of genes with predefined gene sets. Unfortunately, these methods do not perform well. A solution is proposed by the SANTA method, which evaluates the experimental results on discovered gene sets based on known and extensive gene networks. In this thesis, we have implemented the method in Orange Bioinformatics. Orange is a well-known data-analysis programme. The Bioinformatics add-on includes specialised functionality for processing genomic data. Furthermore, we have also enriched its widgets for access to BioGRID and STRING, which store information on functional sets of genes and interactions.

Keywords:Python, Orange, bioinformatics, network, SANTA, STRING, BioGRID

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