Kontaminacija raztopin za parenteralno aplikacijo s steklenimi delci

Černjač Subotič, Timotej (author), Bobnar, Albina (mentor), Fink, Rok (comentor)

Uvod: V strokovni literaturi je opisano, da lahko ob odpiranju steklene ampule pride do kontaminacije raztopine s steklenimi delci, ki se lahko aspirirajo v brizgalko skupaj z raztopino in se aplicirajo pacientu. Namen: Namen diplomskega dela je preučiti kontaminacijo raztopin za parenteralno aplikacijo s steklenimi delci iz ampul po aspiraciji z aspiracijskimi iglami različnih premerov ter z ali brez filtra. Metode dela: V pilotnem poskusu se je v 10 ampulah različnih volumnov ugotavljala prisotnost steklenih delcev v celotni vsebini ampul brez uporabe aspiracijskih igel. Pri ostalih 180 ampulah, uvrščenih po velikosti v 3 skupine, pa je bila njihova vsebina aspirirana z aspiracijskimi iglami treh različnih premerov, ki so bile po aspiraciji zavržene, raztopina brizgalke pa izbrizgana na filtrirni papir za štetje delcev pod mikroskopom. Rezultati: Vsi vzorci pilotnega poskusa so bili kontaminirani s steklenimi delci. Analiza ostalih vzorcev je pokazala, da je do kontaminacije s steklenimi delci prišlo pri 65 % vzorcev aspiriranih z iglo s premerom 18 gauge, pri 78,3 % vzorcev, aspiriranih z iglo s premerom 23 gauge ter pri 5 % vzorcev, aspiriranih z aspiracijsko iglo s premerom 18 gauge z vgrajenim 5-mikronskim plastičnim filtrom BDTM. Pri uporabi aspiracijske igle s filtrom je bilo število steklenih delcev v aspirirani raztopini manjše v primerjavi z aspiracijsko iglo s premerom 18 gauge (p < 0,05). Število steklenih delcev v aspirirani raztopini z aspiracijsko iglo 23 gauge je bilo večje v primerjavi z aspiracijsko iglo s premerom 18 gauge, saj je bilo pri vzorcih, aspiriranih s slednjo, za 64 % manj steklenih delcev (p < 0,05). Razprava in sklep: Uporaba aspiracijske igle s filtrom bistveno pripomore k zmanjšanju kontaminacije aspirirane raztopine s steklenimi delci ter s tem omogoča bolj varno parenteralno aplikacijo pacientom.

• Language: Slovenian
• Keywords: varnost pacienta, steklene ampule, priprava raztopin, filtracija
• Work type: Bachelor thesis/paper
• Organization: ZF - Faculty of Health Sciences
• Year: 2017
• PID: 20.500.12556/RUL-88915
• COBISS.SI-ID: 5231467
• Publication date in RUL: 31.01.2017

Secondary language

• Language: English
• Title: Glass particle contamination of solutions for parenteral use

Abstract

Introduction: Glass particle contamination of solutions that results from the cracking of glass ampules has been demonstrated in literature. These glass particles can be aspirated to syringe along with the solution from the ampule and administered to the patient. Purpose: The purpose of the diploma thesis is to inspect glass particle contamination of solutions for parenteral use after aspiration with drawing-up needles of different gauges and with or without filters. Methods: Ten glass ampules of various volumes were cracked open in the pilot experiment where glass particles were being searched for without the use of aspiration needle. Other 180 ampules were divided by volume into three groups and were aspirated with an aspiration needles of three different gauges that were discarded after each aspiration. The solution was then extruded on white filter paper which was examined under microscopy. Results: All 10 samples of the pilot experiment were contaminated with glass particles. The analysis of the remaining samples demonstrated that glass particle contamination was present in 65 % of the samples aspirated with the 18-gauge needle, 78.3 % of the samples aspirated with the 23-gauge needle and in 5 % of the samples aspirated with the 18-gauge needle with a built in 5-micron plastic filter BDTM. The results identified that the use of a filtered drawing-up needle reduces the total number of glass particles in aspirated solutions in comparison to 18-gauge needle (p< 0.05). The number of glass particles in samples aspirated through 23-gauge needle was higher compared to the 18-gauge drawing-up needle. The latter has shown a 64 % reduction in number of glass particles (p< 0.05). Discussion and Conclusion: The use of filtered drawing-up needle significantly decreases contamination of solutions during aspiration from ampules thus contributes to a safer parenteral application of solutions to the patients.

• Keywords: patient safety, glass ampules, filtration, solution preparation