Vpliv vnosa vode na koncentracijo mikroveziklov v periferni krvi : diplomsko delo

Vogrinec, Tina (author), Bešter-Rogač, Marija (mentor), Kralj-Iglič, Veronika (comentor)

V sklopu diplomske naloge smo želeli izdelati študijo populacije zdravih oseb, ki bi obravnavala vpliv vnosa tekočine na koncentracijo mikroveziklov v izolatih iz periferne krvi. Ugotovili smo, da se je koncentracija celičnih mikroveziklov v izolatih iz krvi znatno (26%) in mejno statistično značilno (p = 0,055) povečala pri preiskovancih, ki so zaužili 30% manj vode kot običajno. Ugotavljali smo tudi koreliranost med koncentracijami posameznih sestavin v urinu in koncentracijo mikroveziklov. Večina koncentracij teh sestavin statistično značilno korelira s koncentracijo mikroveziklov. Med koncentracijami posameznih sestavin krvne plazme in celic v krvi na eni strani ter koncentracijo mikroveziklov na drugi strani pa razen v dveh primerih (natrij, kloridi) nismo ugotovili statistično pomembne koreliranosti.

• Language: Slovenian
• Keywords: voda, membranski mikrovezikli, homeostaza, hidracija, pretočna citometrija
• Work type: Undergraduate thesis
• Typology: 2.11 - Undergraduate Thesis
• Organization: PEF - Faculty of Education
• Publisher: [T. Vogrinec]
• Year: 2016
• Number of pages: IX, 40 f.
• PID: 20.500.12556/RUL-86807
• UDC: 577(043.2)
• COBISS.SI-ID: 11284041
• Publication date in RUL: 05.09.2017

Secondary language

• Language: English
• Title: The impact of water intake on concentrations of mikrovesicles in peripheral blood

Abstract

Within the thesis we wanted to make a study on a population of healthy individuals, which would address the impact of liquids intake on concentration of isolated microvesicles from peripheral blood. We found a significant (26%) and marginally statistically significant (p = 0,055) increase of concentration of isolated microvesicles from blood in subjects, who have consumed 30% less water than usual. We also determined a correlation between individual components in urine and the contreation of microvesicles. Most of the concentrations of those components are in statistically significant correlation with the concentration of microvesicles. We haven't found any statistically significant correlation between the concentrations of individual components of blood plasma and blood cells on the one hand, and the concetration of microvesicles on the other, except in two cases (sodium, chlorides).

• Keywords: biochemistry, biokemija