Primerjava določanja encimov aspartat transferaze (AST) in alanin transferaze (ALT) pri hepatitisu in alkoholni jetrni cirozi : diplomska naloga

Bratina, Katarina (avtor), Osredkar, Joško (mentor)

V diplomski nalogi smo primerjali določitev encimov aspartat aminotransferaze (AST) in alanin aminotransferaze (ALT) pri hepatitisu in alkoholni jetrni cirozi. Zanimalo nas je, ali obstajajo razlike v razmerju AST/ALT encimov pri hepatitisu in alkoholni jetrni cirozi ter med spoloma pri cirozi jeter. Izhodišče za izračun razmerja so nam predstavljale vrednosti encimov pridobljene s kinetično metodo. S tem izračunom smo skušali prispevati k večji specifičnosti pri interpretaciji rezultatov. Statistično smo ugotovili, da o domnevni razliki v razmerju AST/ALT encimov med spoloma ne moremo trditi ničesar, saj so te razlike med njima zgolj naključne. Pri alkoholni jetrni cirozi je aritmetična sredina razmerja AST/ALT enaka 2,12. S tem smo potrdili domnevno trditev AST/ALT>1. Vrednosti za hepatitis odstopajo od pričakovanih (AST/ALT<1). Aritmetična sredina razmerja AST/ALT znaša 1,91. Do odstopanj je prišlo zaradi razmeroma majhne populacije preiskovancev. T-test je pokazal, da so razlike med razmerjem AST/ALT pri alkoholni cirozi in hepatitisu zgolj slučajne, tako da o razlikah med njima ne moremo trditi ničesar. Povzamemo lahko, da je določanje razmerja AST/ALT nezadosten pokazatelj alkoholne jetrne ciroze ter hepatitisa in da na podlagi naših ugotovitev ne moremo sklepati na značilnost populacije.

• Jezik: Slovenski jezik
• Ključne besede: bolezni jeter diagnostika encimi statistična analiza AST ALT
• Vrsta gradiva: Diplomsko delo
• Tipologija: 2.11 - Diplomsko delo
• Organizacija: FFA - Fakulteta za farmacijo
• Kraj izida: Ljubljana
• Založnik: [K. Bratina]
• Leto izida: 2010
• Št. strani: VIII, 52 f.
• PID: 20.500.12556/RUL-71078
• UDK: 616-074
• COBISS.SI-ID: 2874225
• Datum objave v RUL: 10.07.2015

Sekundarni jezik

• Jezik: Angleški jezik
• Naslov: Comparison of determining the enzyme aspartate-aminotransferase and alanine-aminotransferase in hepatitis and alcoholic liver chirrosis

Izvleček

In this thesis, we have compared the determination of enzyme aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in hepatitis and alcoholic liver cirrhosis. We investigated whether there are differences in the ratio of AST / ALT enzymes in hepatitis and alcoholic liver cirrhosis and between the sexes in liver cirrhosis. AST/ALT ratio was calculated from enzyme values obtained by kinetic method. With this method we seek to contribute to greater specificity in the interpretation of results. Statistically, we found that alleged differences in AST/ALT ratio between genders cannot be confirmed nor denied. In alcoholic liver cirrhosis, the average ratio of AST / ALT is 2,12. With this, we have confirmed the alleged claim of AST / ALT > 1. Values for hepatitis are deviating from the expected (AST / ALT <1). The average ratio of AST / ALT amounted to 1,91. This deviation is a consequence of a relatively small population of subjects. T-test showed that differences between the average ratio of AST / ALT in alcoholic cirrhosis and hepatitis are random, meaning that we cannot claim anything about them. It can be concluded that the determination of the ratio of AST / ALT is inadequate indicator of alcoholic liver cirrhosis and hepatitis and that on the basis of our findings, we cannot infer on the characteristics of the population.

• Ključne besede: Aspartate aminotransferase alanine aminotransferase alcoholic liver cirrhosis hepatitis