Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-gammacoactivator-1 gene might be a risk factor for diabetic retinopathy in Slovene population (Caucasians) with type 2 diabetes and the Pro12Ala polymorphism of the PPARgamma gene is not

Globočnik Petrovič, Mojca (author), Kunej, Tanja (author), Peterlin, Borut (author), Dovč, Peter (author), Petrovič, Danijel (author)

Background: The peroxisome proliferator-activated receptor-gamma (PPARgamma) gene has been recently associated with type 2 diabetes, obesity and traits depending on VEGF expression (e.g. retinopathy). The PPARgamma gene and its coactivator, the peroxisome proliferator-activated receptor-gamma coactivator-1 (PPARGC1) gene, have been implicated to be involved in glucose uptake and altered lipid oxidation. We therefore hypothesized that the Gly482Ser polymorphism of the PPARGC1 gene and Pro12Ala polymorphism of the PPARgamma gene might confer susceptibility to diabetic retinopathy in type 2 diabetes. The aim of this study was to investigate the association between thePro12Ala polymorphism in the PPARgamma gene and Gly482Ser polymorphism in the PPARGC1 gene and the development of diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes. Methods: One hundred and sixty subjects with type 2 diabetes and diabetic retinopathy were compared with 101 diabetic subjects without diabetic retinopathy. Chi-square test was used to compare discrete variables, and continuous clinical data were compared by unpaired students t - test. RESULTS: A significantly higher frequency of the AA genotype of the Gly482Ser polymorphism of the PPARGC1 gene was found in thepatients with diabetic retinopathy compared to the patients without diabetic retinopathy (14.4% vs 5.9%; p = 0.035), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to yield an association with diabetic retinopathy. Conclusions: The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas thePro12Ala polymorphism of the PPARgamma gene failed to confer susceptibilityto diabetic retinopathy.

• Language: English
• Work type: Not categorized
• Typology: 1.01 - Original Scientific Article
• Organization: BF - Biotechnical Faculty
• Year: 2005
• Number of pages: Str. 470-474
• Numbering: Letn. 21, št. 5
• PID: 20.500.12556/RUL-36598
• UDC: 61
• ISSN on article: 1520-7552
• COBISS.SI-ID: 19000025
• Publication date in RUL: 10.07.2015

Record is a part of a journal

• Title: Diabetes/metabolism research and reviews
• Shortened title: Diabetes Metab Res Rev
• Publisher: Wiley
• ISSN: 1520-7552
• COBISS.SI-ID: 1966868