Introduction: RED-s syndrome is a physiological function disorder caused by insufficient energy availability and includes impairments in metabolism, menstrual and reproductive function, bones, protein synthesis, and the immune and cardiovascular systems. The basis for the occurrence of RED-s is low energy availability. RED-s syndrome increases the likelihood of injuries, causes decreased training response, slower recovery, reduced cognitive function, motivation, and concentration, decreased muscle strength, endurance and power performance. Purpose: This thesis aims to use literature review to determine, whether female athletes with RED-s syndrome are more prone to musculoskeletal injuries compared to those without the syndrome. Methods: The literature search was conducted using the next online databases: PubMed, Cochrane Library and PEDro. Inclusion criteria for the selected articles included original scientific articles in English, published after 2014. Results: Out of 50 articles found in the databases, 8 studies met the inclusion criteria and were included in the literature review. The findings suggest that athletes at a higher risk of developing RED-s syndrome are more susceptible to musculoskeletal injuries compared to those at a lower risk. The most frequently reported were lower limb injuries. Discussion and conclusion: Physiotherapist who identifies the signs of RED-s syndrome can refer the athlete suspected of low energy availability to a sports medicine physician or dietitian in a timely manner. By collaborating with multidisciplinary team, physiotherapist can also adjust training intensity and volume and addresses injuries resulting from the syndrome. To better understand the consequences of RED-s syndrome, longitudinal studies with a sufficient number of high-risk athletes and standardized measurment tools are necessary. Additionally, practical guidelines for treating RED-s sydrome and ensuring a safe return to competition should be developed and implemented.
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