Integrating genetic insights, technological advancements, screening, and personalized pharmacological interventions in childhood obesity

Šket, Robert (author), Slapnik, Barbara (author), Kotnik, Primož (author), Črepinšek, Klementina (author), Čugalj Kern, Barbara (author), Tesovnik, Tine (author), Jenko Bizjan, Barbara (author), Vrhovšek, Blaž (author), Remec, Žiga Iztok (author), Debeljak, Maruša (author), Battelino, Tadej (author), Kovač, Jernej (author)

Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.6% in girls and 0.9% to 7.8% in boys highlights the urgency of addressing this epidemic. By 2025, it is estimated that 206 million children and adolescents aged 5–19 years will be living with obesity. This review explores the complex interplay of genomics and genetics in pediatric obesity, transitioning from monogenic and polygenic obesity to epigenetics, and incorporating advancements in omics technologies. The evolutionary purpose of adiposity, systemic evaluation of hyperphagia, and the role of various genetic factors are discussed. Technological advancements in genotyping offer new insights and interventions. The integration of genetic screening into clinical practice for early identification and personalized treatment strategies is emphasized.

• Language: English
• Keywords: childhood obesity, genomics, genetics, screening, technological advancements, personalized treatment strategies
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: Str. 72–93
• Numbering: Vol. 42, iss. 1
• PID: 20.500.12556/RUL-166995
• UDC: 61
• ISSN on article: 1865-8652
• DOI: 10.1007/s12325-024-03057-8
• COBISS.SI-ID: 220836611
• Publication date in RUL: 03.02.2025

Record is a part of a journal

• Title: Advances in therapy
• Shortened title: Adv. ther.
• Publisher: Springer Nature, Adis
• ISSN: 1865-8652
• COBISS.SI-ID: 516083481

Licences

• License: CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
• Link: http://creativecommons.org/licenses/by-nc/4.0/
• Description: A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: J3-50122
• Name: Genomsko presejanje novorojenčkov

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P3-0343
• Name: Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih