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Exploring early DNA methylation alterations in type 1 diabetes : implications of glycemic control
ID Čugalj Kern, Barbara (Avtor), ID Kovač, Jernej (Avtor), ID Šket, Robert (Avtor), ID Tesovnik, Tine (Avtor), ID Jenko Bizjan, Barbara (Avtor), ID Galhardo, Julia (Avtor), ID Battelino, Tadej (Avtor), ID Bratina, Nataša (Avtor), ID Dovč, Klemen (Avtor)

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URLURL - Izvorni URL, za dostop obiščite https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1416433/full Povezava se odpre v novem oknu

Izvleček
Background: Prolonged hyperglycemia causes diabetes-related micro- and macrovascular complications, which combined represent a significant burden for individuals living with diabetes. The growing scope of evidence indicates that hyperglycemia affects the development of vascular complications through DNA methylation. Methods: A genome-wide differential DNA methylation analysis was performed on pooled peripheral blood DNA samples from individuals with type 1 diabetes (T1D) with direct DNA sequencing. Strict selection criteria were used to ensure two age- and sex-matched groups with no clinical signs of chronic complications according to persistent mean glycated hemoglobin (HbA1c) values over 5 years: HbA1c<7% (N=10) and HbA1c>8% (N=10). Results: Between the two groups, 8385 differentially methylated CpG sites, annotated to 1802 genes, were identified. Genes annotated to hypomethylated CpG sites were enriched in 48 signaling pathways. Further analysis of key CpG sites revealed four specific regions, two of which were hypermethylated and two hypomethylated, associated with long non-coding RNA and processed pseudogenes. Conclusions: Prolonged hyperglycemia in individuals with T1D, who have no clinical manifestation of diabetes-related complications, is associated with multiple differentially methylated CpG sites in crucial genes and pathways known to be linked to chronic complications in T1D.

Jezik:Angleški jezik
Ključne besede:type 1 diabetes, glycemic control, DNA methylation, diabetes-related complications, long-read sequencing
Vrsta gradiva:Članek v reviji
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Status publikacije:Objavljeno
Različica publikacije:Objavljena publikacija
Leto izida:2024
Št. strani:10 str.
Številčenje:Vol. 15, art. 1416433
PID:20.500.12556/RUL-166831 Povezava se odpre v novem oknu
UDK:61
ISSN pri članku:1664-2392
DOI:10.3389/fendo.2024.1416433 Povezava se odpre v novem oknu
COBISS.SI-ID:198843395 Povezava se odpre v novem oknu
Datum objave v RUL:27.01.2025
Število ogledov:142
Število prenosov:25
Metapodatki:XML DC-XML DC-RDF
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Gradivo je del revije

Naslov:Frontiers in endocrinology
Založnik:Frontiers Media
ISSN:1664-2392
COBISS.SI-ID:3340154 Povezava se odpre v novem oknu

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Projekti

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:P3-0343
Naslov:Etiologija, zgodnje odkrivanje in zdravljenje bolezni pri otrocih in mladostnikih

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:J7-1820
Naslov:Povezava nihanja ravni glukoze in vzorcev metilacije DNK z zgodnjimi znaki okvare očesne mrežnice in ledvic pri posameznikih s sladkorno boleznijo tipa 1

Financer:Drugi - Drug financer ali več financerjev
Program financ.:ISPAD, JDRF Fellowship

Financer:Drugi - Drug financer ali več financerjev
Program financ.:ESPE, Fellowship

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