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Biocompatible polyelectrolyte multilayers with copper oxide and zinc oxide nanoparticles for inhibiting bacterial growth
ID Matijaković Mlinarić, Nives (Author), ID Altenried, Stefanie (Author), ID Selmani, Atiđa (Author), ID Nikolić, Juraj (Author), ID Učakar, Aleksander (Author), ID Zore, Anamarija (Author), ID Abram, Anže (Author), ID Lehner, Sandro (Author), ID Sever Škapin, Andrijana (Author), ID Kušter, Monika (Author), ID Roblegg, Eva (Author), ID Kovačević, Davor (Author), ID Ren, Qun (Author), ID Bohinc, Klemen (Author)

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Abstract
The prevalence of bacterial infections presents a significant challenge in the medical field, demanding effective strategies to impede bacterial adhesion and growth on various surfaces. The conducted study investigates the efficacy of polyelectrolyte multilayers─comprising poly(allylamine hydrochloride) (PAH) and alginate (ALG)─embedded with zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) to inhibit bacterial adhesion on stainless-steel surfaces. Surface characterization involved zeta potential, contact angle, and roughness assessments. The effect of NP composition, size, and morphology in conjunction with polycation or polyanion terminating multilayers was evaluated against planktonic and surface-adhered Escherichia coli (E. coli) cells. Surfaces with the positively charged PAH-terminating multilayer displayed higher water contact angles (≈ 63°) than the negatively charged ALG-terminating multilayers (≈ 45°). Multilayers containing ZnO NPs showed a significant inhibition of planktonic E. coli growth, >99%. Moreover, complete growth inhibition of surface-adhered E. coli was achieved for multilayers containing both ZnO and CuO. Due to their larger specific surface area, rod-like ZnO NPs displayed higher antibacterial activity. The samples with ALG as the terminating layer showed more substantial antibacterial properties than samples with PAH as the terminating layer. Biocompatibility tests on immortalized human keratinocyte cells revealed good compatibility with multilayers incorporating NPs. In summary, this study underscores the potential of ZnO and CuO NPs within PAH/ALG multilayers for antibacterial applications without compromising their cytocompatibility.

Language:English
Keywords:polyelectrolyte multilayers, alginate, poly(allylamine hydrochloride), CuO, ZnO, nanoparticles, Escherichia coli
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:ZF - Faculty of Health Sciences
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2024
Year:2024
Number of pages:Str. 12551-12563
Numbering:Vol. 7, iss.11
PID:20.500.12556/RUL-166703 This link opens in a new window
UDC:577:579
ISSN on article:2574-0970
DOI:10.1021/acsanm.4c00981 This link opens in a new window
COBISS.SI-ID:195799811 This link opens in a new window
Publication date in RUL:22.01.2025
Views:133
Downloads:34
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Record is a part of a journal

Title:ACS applied nano materials
Shortened title:ACS appl. nano mater.
Publisher:American Chemical Society
ISSN:2574-0970
COBISS.SI-ID:32649255 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Projects

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:P2-0273-2019
Name:Gradbeni objekti in materiali

Funder:ARIS - Slovenian Research and Innovation Agency
Project number:N1-0264-2022
Name:Antibakterijske in protivirusne lastnosti nano prevlečenih površin

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