Long-term infection with a particular human papillomavirus (HPV) genotype, HPV subtype, or HPV genomic variant does not significantly influence the clinical course of recurrent respiratory papillomatosis

Gluvajić, Daša (author), Hošnjak, Lea (author), Zorec, Tomaž Mark (author), Gale, Nina (author), Hočevar-Boltežar, Irena (author), Poljak, Mario (author)

Recurrent respiratory papillomatosis (RRP) is caused by human papillomaviruses (HPV) 6 and 11, but the role of their genomic variants in the disease's clinical course is unclear. This study investigated whether long-term persistence of a particular HPV genotype, subtype or genomic variant influences the RRP clinical course. HPV genotyping was performed in paired baseline and follow-up RRP laryngeal tissue specimens of 59 patients. HPV6 and HPV11 genomic variants were determined in paired tissue specimens taken at least 10 years apart in 20 selected patients. HPV was identified in 58/59 patients, most commonly HPV6 (40/58), followed by HPV11 (17/58). The most prevalent HPV genomic variant was HPV11 A2. HPV6 A and HPV6 B1 were most frequent in aggressive RRP. In all patients, identical HPV genomic variants were identified in both paired specimens. RRP results from a long-term infection with the same HPV genomic variant that can be identified decades after disease onset. We report the longest duration of genetically confirmed persistent HPV infection in peer-reviewed literature, during a 44-year interval in a patient with HPB6 B1. This study suggests that infection with a particular HPV genotype, subtype, or genomic variant does not significantly influence the clinical course of RRP.

• Language: English
• Keywords: HPV, genomic variant, human papillomaviruses, laryngeal papilloma, persistence, recurrent respiratory papillomatosis
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: 10 str.
• Numbering: Vol. 96, iss. 11, art. e70060
• PID: 20.500.12556/RUL-165335
• UDC: 578
• ISSN on article: 1096-9071
• DOI: 10.1002/jmv.70060
• COBISS.SI-ID: 217039363
• Publication date in RUL: 02.12.2024

Record is a part of a journal

• Title: Journal of medical virology
• Shortened title: J. med. virol.
• Publisher: Wiley
• ISSN: 1096-9071
• COBISS.SI-ID: 512820505

Licences

• License: CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
• Link: http://creativecommons.org/licenses/by-nc/4.0/
• Description: A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

• Language: Slovenian
• Keywords: HPV, genomska različica, humani papiloma virusi, papilom grla, vztrajnost, ponavljajoča se respiratorna papilomatoza