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Elektrodepozicija hidrogelov na osnovi hitozana in polivinil alkohola z uporabo bakrenih elektrod
ID Atelšek, Maruša (Author), ID Ambrožič, Rok (Mentor) More about this mentor... This link opens in a new window

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Abstract
Hitozan je pomemben naravni polisaharid, ki se pridobiva z deacetilacijo hitina, ki je prisoten v skeletih žuželk, rakov in gliv. Je kationski polisaharid, ki se pogosto uporablja v biomedicini. Še posebej je cenjen zaradi svoje sposobnosti tvorbe hidrogelov, tridimenzionalnih mrež z visoko vsebnostjo vode. Hidrogeli iz hitozana so izredno pomembni zaradi svoje uporabe v medicini, pri dostavi zdravil, tkivnem inženirstvu ter regenerativni medicini. Polivinil alkohol (PVA) je sintetični polimer, ki se lahko v kombinaciji z hitozanom uporablja za izboljšanje lastnosti hidrogelov. Tudi PVA je znan po svoji biokompatibilnosti in netoksičnosti, prav tako pa je njegova lastnost tudi dobra mehanska trdnost, kar ga naredi idealnega za uporabo v medicinskih aplikacijah. Ko PVA kombiniramo s hitozanom, nastane kompozitni hidrogel, ki združuje prednosti obeh materialov. Skupaj omogočata natančno kontrolo nad lastnostmi hidrogela, kar odpira možnosti za raziskovanje naprednih sistemov za nadzorovano sproščanje zdravil, prilagodljive materiale za tkivno inženirstvo ter inovativne rešitve za zdravljenje ran in regeneracijo tkiv. Postopek tvorbe hidrogelov hitozana in PVA z elektrodepozicijo temelji na katodni nevtralizaciji, kjer lokalni pH gradient ob katodni površini povzroči prehod hitozana iz raztopine v gel, kar omogoča stabilno nalaganje hidrogela na površino katode. V prisotnosti bakrovih ionov, ki nastanejo na anodi, pride do koordinacijske elektrodepozicije, kjer baker sodeluje pri tvorbi stabilnega hidrogelnega premaza. Ta metoda omogoča izdelavo hidrogelov z izboljšano stabilnostjo in možnostjo natančne kontrole nad strukturo, kar je ključnega pomena za nadaljnje raziskave.

Language:Slovenian
Keywords:hitozan, hidrogel, elektrodepozicija, PVA, difuzija
Work type:Master's thesis/paper
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2024
PID:20.500.12556/RUL-165259 This link opens in a new window
Publication date in RUL:28.11.2024
Views:24
Downloads:2
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Secondary language

Language:English
Title:Electrodeposition of Chitosan and Polyvinyl Alcohol-Based Hydrogels Using Copper Electrodes
Abstract:
Chitosan is an important natural polysaccharide derived from the deacetylation of chitin, which is found in the exoskeletons of insects, crustaceans, and fungi. It is a cationic polysaccharide widely used in biomedicine, particularly valued for its ability to form hydrogels—three-dimensional networks with high water content. Chitosan-based hydrogels are crucial in medicine, especially in drug delivery, tissue engineering, and regenerative medicine. Polyvinyl alcohol (PVA) is a synthetic polymer that can be combined with chitosan to enhance the properties of hydrogels. PVA is also known for its biocompatibility and non-toxicity, along with its excellent mechanical strength, making it ideal for use in medical applications. When PVA is combined with chitosan, a composite hydrogel is formed, which merges the benefits of both materials. Together, they allow precise control over the hydrogel's properties, paving the way for exploring advanced systems for controlled drug release, adaptable materials for tissue engineering, and innovative solutions for wound healing and tissue regeneration. The process of forming chitosan and PVA hydrogels through electrodeposition is based on cathodic neutralization, where the localized pH gradient at the cathode surface causes chitosan to transition from solution to gel, enabling stable deposition of the hydrogel onto the cathode surface. In the presence of copper ions generated at the anode, coordination electrodeposition occurs, with copper aiding in the formation of a stable hydrogel coating. This method allows the production of hydrogels with enhanced stability and precise structural control, which is essential for further research.

Keywords:chitosan, hydrogel, electrodeposition, PVA, diffusion

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