From fallopian tube epithelium to high-grade serous ovarian cancer : a single-cell resolution review of sex steroid hormone signaling

Gjorgoska, Marija (avtor), Lanišnik-Rižner, Tea (avtor)

High-grade serous ovarian cancer (HGSOC) represents the most lethal subtype of ovarian cancer, largely due to being commonly diagnosed at advanced stages. The early molecular mechanisms underlying ovarian carcinogenesis remain poorly defined, posing challenges to the development of prevention and early detection strategies. Here we dissect the molecular mechanisms of sex steroid hormone signaling throughout the decades-long evolution of HGSOC precursor lesions, which predominantly originate from secretory epithelial cells of fallopian tubes (FT). We also discuss the prognostic significance of sex steroid receptor isoforms and steroid metabolizing enzymes in HGSOCs. Finally, we provide a comprehensive gene expression atlases of sex steroid receptors, steroidogenic, and steroid-metabolizing enzymes across different cell populations in pre- and postmenopausal FTs, and HGSOCs, using published single-cell RNA sequencing datasets. These atlases reveal that secretory epithelial cells and stromal populations in FTs express sex steroid receptors and enzymes responsible for the formation and inactivation of genotoxic estrogen metabolites. In HGSOC, epithelial cells express various HSD17B isoforms and steroid conjugating enzymes, suggesting an enhanced ability to finely regulate the levels of bioactive sex steroids.

• Jezik: Angleški jezik
• Ključne besede: androgens, estrogens, high-grade serous ovarian cancer, progestogens, serous tubal intraepithelial carcinoma, sex steroid receptors
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 10 str.
• Številčenje: Vol. 96, art. 101302
• PID: 20.500.12556/RUL-165164
• UDK: 577.2
• ISSN pri članku: 1873-2194
• DOI: 10.1016/j.plipres.2024.101302
• COBISS.SI-ID: 216006659
• Datum objave v RUL: 25.11.2024

Gradivo je del revije

• Naslov: Progress in lipid research
• Založnik: Elsevier
• ISSN: 1873-2194
• COBISS.SI-ID: 175211779

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: androgeni, estrogeni, serozni rak jajčnikov visoke stopnje, progestogeni, receptorji za spolne steroide

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: J3-2535
• Naslov: Vloga androgenov pri hormonsko odvisnih boleznih: pomen za diagnostiko in zdravljenje

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0449
• Naslov: Translacijska molekularna endokrinologija za zdravje žensk