The contribution of type 2 diabetes to Parkinson's disease aetiology

Ribarič, Samo (author)

Type 2 diabetes (T2D) and Parkinson's disease (PD) are chronic disorders that have a significant health impact on a global scale. Epidemiological, preclinical, and clinical research underpins the assumption that insulin resistance and chronic inflammation contribute to the overlapping aetiologies of T2D and PD. This narrative review summarises the recent evidence on the contribution of T2D to the initiation and progression of PD brain pathology. It also briefly discusses the rationale and potential of alternative pharmacological interventions for PD treatment.

• Language: English
• Keywords: Parkinson’s disease, advanced glycation end products, diabetes, hyperglycemia, insulin resistance, neuroinflammation, reactive oxidative species, ROS, α-synuclein, α-synuclein oligomers
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: 44 str.
• Numbering: Vol. 25, iss. 8, art. 4358
• PID: 20.500.12556/RUL-164947
• UDC: 616-092
• ISSN on article: 1422-0067
• DOI: 10.3390/ijms25084358
• COBISS.SI-ID: 194916099
• Publication date in RUL: 18.11.2024

Record is a part of a journal

• Title: International journal of molecular sciences
• Shortened title: Int. j. mol. sci.
• Publisher: MDPI
• ISSN: 1422-0067
• COBISS.SI-ID: 2779162

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: Parkinsonova bolezen, napredni končni produkti glikacije, sladkorna bolezen, hiperglikemija, odpornost proti inzulinu, nevrovnetje, reaktivne oksidativne vrste, ROS, α-sinuklein, oligomeri α-sinukleina

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P3-0171
• Name: Plastičnost živčevja v fizioloških in patofizioloških razmerah