Compensational role between cathepsins

Pečar Fonović, Urša (avtor), Kos, Janko (avtor), Mitrović, Ana (avtor)

Cathepsins, a family of lysosomal peptidases, play a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation as well as many specific regulatory actions that are important for proper cell function and human health. Alterations in the activity and expression of cathepsins have been observed in many diseases such as cancer, inflammation, neurodegenerative disorders, bone remodelling-related conditions and others. These changes are not exclusively harmful, but rather appear to be a compensatory response on the lack of one cathepsin in order to maintain tissue integrity. The upregulation of specific cathepsins in response to the inhibition or dysfunction of other cathepsins suggests a fine-tuned system of proteolytic balance and understanding the compensatory role of cathepsins may improve therapeutic potential of cathepsin's inhibitors. Selectively targeting one cathepsin or modulating their activity could offer new treatment strategies for a number of diseases. This review emphasises the need for comprehensive research into cathepsin biology in the context of disease. The identification of the specific cathepsins involved in compensatory responses, the elucidation of the underlying molecular mechanisms and the development of targeted interventions could lead to innovative therapeutic approaches.

• Jezik: Angleški jezik
• Ključne besede: lysosomal peptidases, compensation, bone resorption, cancer, inflammation, neurodegeneration
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: Str. 62-76
• Številčenje: Vol. 226
• PID: 20.500.12556/RUL-164680
• UDK: 577
• ISSN pri članku: 1638-6183
• DOI: 10.1016/j.biochi.2024.04.010
• COBISS.SI-ID: 193579011
• Datum objave v RUL: 07.11.2024

Gradivo je del revije

• Naslov: Biochimie
• Skrajšan naslov: Biochimie
• Založnik: Elsevier, Société Française de Biochimie et Biologie Moléculaire
• ISSN: 1638-6183
• COBISS.SI-ID: 193576195

Licence

• Licenca: CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
• Opis: Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: katepsini, rak, vnetje, nevrodegenerativne bolezni

Projekti

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: J3-3071
• Naslov: Katepsina B in X v tumorskih matičnih celicah raka dojke – molekulske tarče in pomen za protitumorno terapijo

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P4-0127
• Naslov: Farmacevtska biotehnologija: znanost za zdravje