Compensational role between cathepsins

Pečar Fonović, Urša (author), Kos, Janko (author), Mitrović, Ana (author)

Cathepsins, a family of lysosomal peptidases, play a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation as well as many specific regulatory actions that are important for proper cell function and human health. Alterations in the activity and expression of cathepsins have been observed in many diseases such as cancer, inflammation, neurodegenerative disorders, bone remodelling-related conditions and others. These changes are not exclusively harmful, but rather appear to be a compensatory response on the lack of one cathepsin in order to maintain tissue integrity. The upregulation of specific cathepsins in response to the inhibition or dysfunction of other cathepsins suggests a fine-tuned system of proteolytic balance and understanding the compensatory role of cathepsins may improve therapeutic potential of cathepsin's inhibitors. Selectively targeting one cathepsin or modulating their activity could offer new treatment strategies for a number of diseases. This review emphasises the need for comprehensive research into cathepsin biology in the context of disease. The identification of the specific cathepsins involved in compensatory responses, the elucidation of the underlying molecular mechanisms and the development of targeted interventions could lead to innovative therapeutic approaches.

• Language: English
• Keywords: lysosomal peptidases, compensation, bone resorption, cancer, inflammation, neurodegeneration
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: Str. 62-76
• Numbering: Vol. 226
• PID: 20.500.12556/RUL-164680
• UDC: 577
• ISSN on article: 1638-6183
• DOI: 10.1016/j.biochi.2024.04.010
• COBISS.SI-ID: 193579011
• Publication date in RUL: 07.11.2024

Record is a part of a journal

• Title: Biochimie
• Shortened title: Biochimie
• Publisher: Elsevier, Société Française de Biochimie et Biologie Moléculaire
• ISSN: 1638-6183
• COBISS.SI-ID: 193576195

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: katepsini, rak, vnetje, nevrodegenerativne bolezni

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: J3-3071
• Name: Katepsina B in X v tumorskih matičnih celicah raka dojke – molekulske tarče in pomen za protitumorno terapijo

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P4-0127
• Name: Farmacevtska biotehnologija: znanost za zdravje