Colloidal silica is an amorphous material that, due to its properties such as inertness, high specific surface area, high porosity, and low density, finds wide use in pharmaceutical production as a glidant, lubricant, and delivery system for poorly soluble active ingredients. However, its poor flow properties hinder its application.
In this master's thesis, we studied the properties of Syloid® 244 FP granulates produced with various binders. We improved the formulations by adding L-HPC LH 22. We also examined the impact of using a combination of two binders. The resulting formulations were evaluated for flow properties, particle size, elastic relaxation, compressibility, and compactibility.
Through granulation, we improved the flow properties of the starting materials, but as the amount of powdered component increased, the flow properties deteriorated. We enhanced the compressibility and compactibility of the initial granulates. The final tablets passed pharmacopoeial tests for uniformity of mass, friability, and disintegration time.
|
