Personalization of thiopurine therapy : current recommendations and future perspectives

Urbančič, Dunja (avtor), Pasha, Flaka (avtor), Šmid, Alenka (avtor), Mlinarič-Raščan, Irena (avtor)

Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease, other autoimmune disorders, and cancer. This review presents the latest guidelines for thiopurine administration, highlighting the importance of individualized therapy guided by pharmacogenomics. It emphasizes dose adjustment based on nudix hydrolase 15 (NUDT15) and thiopurine S-methyltransferase (TPMT) genotype, alongside thiopurine S-methyltransferase activity and thiopurine metabolic profile. In addition, the article takes a critical look at emerging research in the field of thiopurine pharmacogenomics featuring novel genetic markers and technological developments in genetic testing. Finally, the potential of integrated approaches that combine genetic, metabolic, and clinical factors to further individualize thiopurine therapy is highlighted.

• Jezik: Angleški jezik
• Ključne besede: thiopurines, TPMT, NUDT15, personalized medicine, therapeutic drug monitoring
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: FFA - Fakulteta za farmacijo
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: Str. 355-381
• Številčenje: Vol. 74, no. 3
• PID: 20.500.12556/RUL-163535
• UDK: 61-027.552
• ISSN pri članku: 1846-9558
• DOI: 10.2478/acph-2024-0030
• COBISS.SI-ID: 206023171
• Datum objave v RUL: 08.10.2024

Gradivo je del revije

• Naslov: Acta pharmaceutica
• Skrajšan naslov: Acta pharm.
• Založnik: Croatian Pharmaceutical Society
• ISSN: 1846-9558
• COBISS.SI-ID: 3817585

Licence

• Licenca: CC BY-ND 4.0, Creative Commons Priznanje avtorstva-Brez predelav 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nd/4.0/deed.sl
• Opis: Licenca Creative Commons Brez predelav dovoljuje uporabnikom ponovno distribucijo dela, vendar ne v spremenjeni obliki. Zahtevana je navedba avtorstva.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: tiopurini, TPMT, NUDT15, terapevtsko spremljanje zdravil, personalizirana medicina