Analytical evaluation and antioxidant activity of welected vegetable oils to support evidence-based use in dermal products

Poljšak, Nina (author), Kočevar Glavač, Nina (author)

This study presents an analytical and biological evaluation of selected vegetable oils and their unsaponifiable compounds,which are of crucial importance for the cosmetic and pharmaceutical industries, with the aim of ensuring their targeted use in dermalproducts. Methods: Vegetable oils were selected based on their dominant fatty acid composition: pomegranate seed oil (punicicacid), linseed oil (α-linolenic acid), coconut oil (lauric acid), olive oil (oleic acid), poppy seed oil (linoleic acid), linden seed oil (linoleicacid), and marigold seed oil (α-calendic acid). Pharmacopoeial chemical values, fatty acid profiles, and unsaponifiable compoundswere analysed. Antioxidant activity was measured using DPPH assay. Results: Chemical values indicated good oxidative status andminimal hydrolysis. Fatty acid analysis revealed expected compositions, with rare linden and marigold seed oils exhibiting distinctivefatty acid composition, featuring sterculic and α-calendic acids. Marigold seed oil showed the richest profile of unsaponifiable com-pounds. Antioxidant activity was highest in olive oil and lowest in coconut oil. No significant correlation was found between the fattyacid composition, unsaponifiable matter, and antioxidant activity suggesting the synergistic or antagonistic interactions of oilcomponents. Conclusion: The study highlights the complex interactions among oil components that influence antioxidant activity.These findings deepen the understanding of the complex mechanisms determining the antioxidant properties of vegetable oils,crucial for informed decisions in dermal product formulation as demand for natural, effective cosmetic and pharmaceutical ingre-dients rises.

• Language: English
• Keywords: antioxidant activity, Calendula, fatty acid composition, pharmacopoeial chemical values, Tilia, unsaponifiable compounds, vegetable oil, bioactivity
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: 10 str.
• Numbering: Vol. 19, no. 9
• PID: 20.500.12556/RUL-163494
• UDC: 54.04:547.466.3+664.34
• ISSN on article: 1555-9475
• DOI: 10.1177/1934578X241281245
• COBISS.SI-ID: 210219011
• Publication date in RUL: 08.10.2024

Record is a part of a journal

• Title: Natural product communications
• Publisher: Natural Product Inc.
• ISSN: 1555-9475
• COBISS.SI-ID: 525775641

Licences

• License: CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
• Link: http://creativecommons.org/licenses/by-nc/4.0/
• Description: A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

• Language: Slovenian
• Keywords: antioksidativno delovanje, ognjič, sestava maščobnih kislin, farmakopejske kemijske vrednosti, tilija, neumiljive spojine, bioaktivnost, maščobne kisline, rastlinska olja, antioksidativna učinkovitost

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P1-0208
• Name: Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin