In my thesis, I described one of the possible synthesis routes of 1-nitroheptadec-1-ene from commercially available palmitic acid and the Michael addition of the tetronic acid to nitroalkene. I conducted the described synthesis in the laboratory, where I carried out the synthesis of the nitroalkene twice in order to compare the results of the two iterations. I carried out the synthesis in five steps via hexadecanal and 1-nitroheptadecan-2-ol, that was formed during the Henry addition of nitromethane to hexadecanal. The key step of the synthesis was the Michael addition, which was carried out under mild reaction conditions and with a high yield using achiral organocatalyst.
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