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Association between autism spectrum disorder, trace elements, and intracranial fluid spaces
ID
Mlinarič, Matej
(
Author
),
ID
Jekovec-Vrhovšek, Maja
(
Author
),
ID
Neubauer, David
(
Author
),
ID
France Štiglic, Alenka
(
Author
),
ID
Osredkar, Joško
(
Author
)
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MD5: 814ECCC4E5FABD9EC0E6AD07DE07D0E7
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https://www.mdpi.com/1422-0067/25/15/8050
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Abstract
Autism spectrum disorder (ASD) belongs to the group of complex developmental disorders. Novel studies have suggested that genetic and environmental factors equally affect the risk of ASD. Identification of environmental factors involved in the development of ASD is therefore crucial for a better understanding of its etiology. Whether there is a causal link between trace elements, brain magnetic resonance imaging (MRI), and ASD remains a matter of debate and requires further studies. (2) In the prospective part of the study, we included 194 children, including an age-matched control group; in the retrospective study, 28 children with available MRI imaging were included. All children had urine analysis of trace elements performed. In those with available brain MRI, linear indexes for the ventricular volumes were measured and calculated. (3) We found the highest vanadium, rubidium, thallium, and silver levels in children with ASD. These elements also correlated with the estimated ventricular volume based on MRI indexes in children with ASD in the subanalysis. However, the severity of the deficits did not correlate with brain MRI indexes of our elements, except negatively with magnesium. (4) Trace elements have an impact on children with ASD, but further multi-centric studies are needed to explain the pathophysiological mechanisms.
Language:
English
Keywords:
autism spectrum disorders
,
trace elements
,
ventricular indexes
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2024
Number of pages:
16 str.
Numbering:
Vol. 25, issue 15, article no. 8050
PID:
20.500.12556/RUL-160067
UDC:
616.896
ISSN on article:
1422-0067
DOI:
10.3390/ijms25158050
COBISS.SI-ID:
203689475
Publication date in RUL:
14.08.2024
Views:
120
Downloads:
25
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Record is a part of a journal
Title:
International journal of molecular sciences
Shortened title:
Int. j. mol. sci.
Publisher:
MDPI
ISSN:
1422-0067
COBISS.SI-ID:
2779162
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
motnje avtističnega spektra
,
elementi v sledovih
,
ventrikularni indeksi
,
avtizem
Projects
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
J3-1756
Name:
Okoljski in genetski dejavniki pri motnjah avtističnega spektra
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
P3-0124
Name:
Metabolni in prirojeni dejavniki reproduktivnega zdravja, porod III
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