Morphological and functional correlations in acute central serous chorioretinopathy

Kiraly, Peter (author), Šuštar Habjan, Maja (author), Smrekar, Jaka (author), Jaki Mekjavić, Polona (author)

Purpose We evaluate morphological and functional correlations in patients with acute central serous chorioretinopathy (CSC). Methods A prospective study was conducted on 50 patients with an acute CSC episode lasting less than 3 months. At baseline, assessments included optical coherence tomography (OCT), best-corrected visual acuity (BCVA), contrast sensitivity (CS), microperimetry (MP), and multifocal electroretinography (mfERG). A correlation analysis between OCT morphological parameters (maximal subretinal fluid height (SRF), central retinal thickness (CRT), and macular volume (MV)) and functional parameters was conducted on the affected eye for each patient. Results Among the morphological parameters, SRF showed the strongest correlations with functional parameters (r absolute value range = 0.10–0.70). Weak correlations were observed between BCVA and morphological parameters (r absolute value range = 0.14–0.26). Average retinal sensitivity (MP-A) was the functional parameter displaying the most robust negative correlation with morphological parameters (r absolute value range = 0.61–0.70). In contrast, average contrast sensitivity (CS-A) and mfERG average amplitude density in the first (mfERG-A1) and second (mfERG-A2) ring showed weak to moderate (r absolute value range = 0.35–0.56) yet statistically significantly nonzero correlations. Conclusions SRF and CRT could serve as the most representative morphological proxies for visual function deficit in acute CSC patients. Retinal sensitivity, as measured by MP, may be superior to BCVA in clinical research studies or when an in-depth visual function evaluation is needed.

• Language: English
• Keywords: central serous chorioretinopathy, CSC, CSR, correlations, morphological correlations, functional correlations
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine; FMF - Faculty of Mathematics and Physics
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: Str. 145–153
• Numbering: Vol. 148, iss. 3
• PID: 20.500.12556/RUL-156346
• UDC: 617.7
• ISSN on article: 1573-2622
• DOI: 10.1007/s10633-024-09969-8
• COBISS.SI-ID: 193402883
• Publication date in RUL: 21.05.2024

Record is a part of a journal

• Title: Documenta ophthalmologica
• Shortened title: Doc. ophthalmol.
• Publisher: Springer Nature
• ISSN: 1573-2622
• COBISS.SI-ID: 513144601

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: centralna serozna horioretinopatija, korelacije, funkcionalne korelacije, morfološke korelacije