2023 global inventory of commercial molecular tests for human papillomaviruses (HPV)

Poljak, Mario (avtor), Oštrbenk Valenčak, Anja (avtor), Cuschieri, Kate S. (avtor), Bohinc, Klara (avtor), Arbyn, Marc (avtor)

To suit the needs of the human papillomaviruses (HPV) community comprehensively, a range of commercial HPV tests with different performance characteristics are required. Four periodic inventories of commercial HPV molecular tests present in the global market were published previously in 2010, 2012, 2015 and 2020. For the fifth inventory, data were retrieved from internal files and a detailed search using the main bibliographic databases as well as general internet search without period or language restrictions was performed in December 2023. At least 264 distinct HPV tests (and 511 test variants) were available globally in December 2023. A small 2020–2023 net increase in total numbers was observed, but with a strong introduction/withdrawal dynamic: 86 new distinct HPV tests (and 141 variants) were introduced and 76 tests (and 55 variants) were withdrawn from the market in the last four years. Although quality improvement of some tests was recorded, half of all HPV tests are still without a single peer-reviewed publication, and 79 % of tests are without published evidence that demonstrate performance characteristics are in line with requirements agreed in the HPV community. Only a relatively small pool of tests fulfill the operational/performance characteristics required to meet the global cervical cancer screening challenge. Although clinical and analytical performance characteristics of many commercial HPV tests are largely unknown, such tests are used worldwide in daily clinical practice and research, with potentially deleterious consequences. Due to this long-lasting unfavorable situation, significant scope for improvement persists for both manufacturers of HPV tests and the HPV community.

• Jezik: Angleški jezik
• Ključne besede: cervical cancer, HPV, human papillomaviruses, screening, test
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.02 - Pregledni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 8 str.
• Številčenje: Vol. 172, art. 105671
• PID: 20.500.12556/RUL-156261
• UDK: 618.1
• ISSN pri članku: 1873-5967
• DOI: 10.1016/j.jcv.2024.105671
• COBISS.SI-ID: 195047171
• Datum objave v RUL: 16.05.2024

Gradivo je del revije

• Naslov: Journal of clinical virology
• Založnik: Elsevier, Pan American Society for Clinical Virology, European Society for Clinical Virology
• ISSN: 1873-5967
• COBISS.SI-ID: 23214341

Licence

• Licenca: CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by-nc/4.0/deed.sl
• Opis: Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: rak materničnega vratu, HPV, humani papiloma virusi, presejanje, test

Projekti

• Financer: EC - European Commission
• Program financ.: H2020
• Številka projekta: 847845
• Naslov: Risk-based screening for cervical cancer
• Akronim: RISCC

• Financer: ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
• Številka projekta: P3-0083
• Naslov: Odnosi parazitskega obstajanja