The lipid peroxidation of polyunsaturated lipids in model membranes (liposomes) can be successfully prevented by using antioxidants. In the experimental part of the master's thesis, we prepared liposomes from phospholipids with multiple polyunsaturated fatty acids. We prepared series of liposomes with the addition of various concentrations of three selected flavonoids. Subsequently, the oxidation of liposomes in oxygen atmosphere followed. We analyzed the lipid content before and after oxidation and at different times of exposure to oxygen. Quantitative analysis was performed using the UHPLC method with a charged aerosol detector (CAD).
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