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The diagnostic accuracy of radiographic cardiac indices in the assessment of cardiomegaly and left atrial enlargement in rat with dilated cardiomyopathy: and experimental study
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Kaya, Mahir
(
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),
ID
Çetinkaya, Mehmet Alper
(
Author
)
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https://slovetres.si/index.php/SVR/article/view/1696
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Abstract
The purpose of this study was to determine the diagnostic value of the ver-tebral heart score (VHS), radiographic left atrial dimension (RLAD), and vertebral left atrial size (VLAS) in the radiographic evaluation of doxorubicin-induced dilated cardio-myopathy (DCM) in rats. The animals were allocated into two experimental groups, a DCM group (n=100), which received weekly injections of doxorubicin (2 mg/kg per dose intraperitoneally [ip]) over nine weeks, and a control group (n=18) receiving an appropri-ate volume of 0.9% saline ip. Radiographic cardiac indices (VHS, RLAD, VLAS) were measured two weeks after the final injection, and cardiac morphological parameters (heart weight [HW], heart weight:body weight ratio [HBW], and heart weight:tibial length ratio [HTL]) were determined after sacrifice in all surviving rats (17 control and 54 DCM). Correlations were calculated between the indices and parameters, as well as their sen-sitivity and specificity in detecting cardiomegaly and left atrial enlargement (LAE) with the three classifiers (HW≤0.96 g, HBW≤235, and HTL≤201). A powerful negative correla-tion was observed between the indices and parameters (rs≥-0.711, P<0.001). Area under the curve values were 0.989 for RL-VHS, 0.992 for DV-VHS, 0.971 for RLAD, and 0.948 for VLAS. The sensitivity and specificity of these indices in detecting cardiomegaly and LAE at the optimal cut-off values were 94.4% and 100%, respectively, at 8.8 vertebrae (v) for RL-VHS and DV-VHS, 96.3% and 94.1% at 1.4v for RLAD, and 94.4% and 88.2% at 2.1v for VLAS. Radiographic cardiac indices offer an accurate and repeatable method for predicting cardiomegaly and LAE in rats with DCM.
Language:
English
Keywords:
dilated cardiomyopathy
,
doxorubicin
,
rat
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
VF - Veterinary Faculty
Publication status:
Published
Publication version:
Version of Record
Publication date:
01.01.2023
Year:
2023
Number of pages:
str. 205-212
Numbering:
Vol. 60, no. 4
PID:
20.500.12556/RUL-155882
UDC:
599.32:303.447.3:544.442:616.12-073.7
ISSN on article:
1580-4003
DOI:
10.26873/SVR-1696-2023
COBISS.SI-ID:
188010755
Publication date in RUL:
23.04.2024
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109
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11
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Title:
Slovenian veterinary research : the scientific journal of the Veterinary Faculty University of Ljubljana
Shortened title:
Slov. vet. res.
Publisher:
Veterinarska fakulteta, Veterinarska fakulteta, Založba Univerze v Ljubljani
ISSN:
1580-4003
COBISS.SI-ID:
108028416
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Title:
Natančnost diagnostike radiografskih kazalcev srca pri ocenjevanju kardiomegalije in povečanja levega preddvora pri podganah z dilatativno kardiomiopatijo: eksperimentalna študija
Keywords:
dilatativna kardiomiopatija
,
doksorubicin
,
podgana
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