Prognostic impact of nutritional status on overall survival and health-related quality of life in men with advanced prostate cancer

Čavka, Luka (avtor), Pohar Perme, Maja (avtor), Rotovnik-Kozjek, Nada (avtor), Šeruga, Boštjan (avtor)

Purpose: Prognostic role of nutritional status (NS) in patients with metastatic castrate-resistant prostate cancer (mCRPC) is unknown. We hypothesized that patients’ NS at the presentation of mCRPC is prognostic for health-related quality of life (HRQoL) and overall survival (OS). Methods: We conducted a prospective observational study in mCRPC patients. At enrollment, we allocated each patient into one of four NS categories: (i) well-nourished (WN), (ii) nutritional risk without sarcopenia/cachexia (NR), (iii) sarcopenia, or (iv) cachexia. We sought the prognostic role of the NS for OS and HRQoL by regression models. Results: 141 patients were included into our study. When compared to WN patients, those with NR and cachexia had a higher chance of worse HRQoL (OR 3.45; 95% CI [1.28 to 9.09], and OR 4.17; 95% CI [1.28 to 12.5], respectively), as well as shorter OS (HR 2.04; 95% CI [1.19 to 3.39] and HR 2.9; 95% CI [1.56 to 5.41], respectively). However, when accounting for possible confounding factors, we could not prove the significant importance of NS for chosen outcomes. Conclusions: Suboptimal NS might be an unfavorable prognostic factor for HRQoL and OS. Further interventional studies focusing on therapy or prevention are warranted.

• Jezik: Angleški jezik
• Ključne besede: metastatic castrate-resistant prostate cancer, nutritional risk, malnutrition, outcomes
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2023
• Št. strani: 12 str.
• Številčenje: Vol. 15, iss. 4, art. 1044
• PID: 20.500.12556/RUL-155619
• UDK: 613.2
• ISSN pri članku: 2072-6643
• DOI: 10.3390/nu15041044
• COBISS.SI-ID: 142236931
• Datum objave v RUL: 08.04.2024

Gradivo je del revije

• Naslov: Nutrients
• Skrajšan naslov: Nutrients
• Založnik: MDPI
• ISSN: 2072-6643
• COBISS.SI-ID: 2948140

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: metastatski na kastracijo odporen rak prostate, prehransko tveganje, podhranjenost

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0321
• Naslov: Napovedni dejavniki poteka bolezni in odgovora na zdravljenje pri različnih vrstah raka