Vpliv sestave in strukture kompozitnih hidrogelov iz TEMPO modificiranih nanoceluloznih vlaken in grafen oksida na reološke lastnosti in sposobnost kontroliranega sproščanja spojin

Jozič, Jernej (author), Šebenik, Urška (mentor)

Za različne hidrogele velja, da posedujejo kombinacijo unikatnih lastnosti, kot so biorazgradljivost, biokompatibilnost, hidrofilnost, superabsorpcija, viskoelastičnost in nestrupenost. Prav unikatne lastnosti so razlog, da jih uporabljamo na več različnih področjih. V zadnjih letih se intenzivno preučuje zmožnost aplikacije hidrogelov v medicinskih in farmacevtskih postopkih kot nosilce za kontrolirano sproščanje učinkovin in tarčno dostavo zdravil. Hidrogeli na osnovi nanoceluloznih vlaken z dodatkom grafen oksida v vodi tvorijo koloidno suspenzijo. Njihove prednosti so obstojnost v širokem temperaturnem območju, delovanje v širokem pH območju in v območju različne ionske moči okolice, biokompatibilnost ter nestrupenost. Z dodatkom grafen oksida se hidrogelom izboljšajo mehanske lastnosti. Med magistrskim delom sem preučeval reološke lastnosti nanoceluloznih hidrogelov z dodatkom grafen oksida. S pomočjo reoloških testov sem spremljal tokovne in viskoelastične lastnosti hidrogelov. Kasneje sem rezultate, pridobljene z reološkimi testi, povezal z učinkovitostjo sproščanja učinkovin teofilina in lizocima iz hidrogelov. Ugotovil sem, da na reološke lastnosti hidrogelov vplivajo starost, stopnja zamreženosti in sestava hidrogelov. Iz rezultatov, pridobljenih na disolucijski napravi, sem lahko sklepal, da dodatek grafen oksida v nanocelulozno suspenzijo nima drastičnega vpliva na kontrolirano sproščanje učinkovin iz hidrogela.

• Language: Slovenian
• Keywords: hidrogel, reologija, strižni modul, kontrolirano sproščanje učinkovin, difuzivnost
• Work type: Master's thesis/paper
• Typology: 2.09 - Master's Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2024
• PID: 20.500.12556/RUL-154947
• COBISS.SI-ID: 189056003
• Publication date in RUL: 11.03.2024

Secondary language

• Language: English
• Title: Effect on composition and structure of TEMPO-oxidized nanofibrillated cellulose composite hydrogels with graphene oxide on rheological properties and the ability of controlled release of compounds

Abstract

Various hydrogels possess a combination of unique properties, such as biodegradability, biocompatibility, hydrophilicity, superabsorption, viscoelasticity, and non-toxicity. Because of these unique properties, hydrogels find applications across various fields. In recent years, there has been intensive research into the potential applications of hydrogels in medical and pharmaceutical procedures, specifically as carriers for the controlled release of active substances and targeted drug delivery. Hydrogels based on nanocellulose fibers with the addition of graphene oxide form a colloidal suspension in water. Their advantages include stability over a wide temperature range, within a broad pH range, and under varying ionic strength conditions in the environment, as well as biocompatibility and non-toxicity. Due to the addition of graphene oxide, hydrogels exhibit improved mechanical properties. During my master's thesis, I investigated the rheological properties of nanocellulose hydrogels with the addition of graphene oxide. Using rheological tests, I described hydrogels' flow and viscoelastic behaviour. Subsequently, I correlated the results obtained from rheological tests with the effectiveness of control release of theophylline and lysozyme from the hydrogels. I found that the rheological properties of hydrogels are influenced by their age, cross-linking density, and composition. Based on the results obtained from controlled release studies, I could conclude that the addition of graphene oxide to the nanocellulose suspension does not have a drastic impact on the controlled release of active substances from the hydrogel.

• Keywords: hydrogel, rheology, shear modulus, controlled drug release, diffusivity