The effect of polymer–solvent interaction on the swelling of polymer matrix tablets: a magnetic resonance microscopy study complemented by bond fluctuation model simulations

Bajd, Franci (avtor), Mikac, Urška (avtor), Mohorič, Aleš (avtor), Serša, Igor (avtor)

Polymer matrix tablets are an important drug-delivery system widely used for oral drug administration. Understanding the tablet hydration process, both experimentally and theoretically, is, thus, very important for the development of drug delivery systems that exhibit high drug loading capacity and controlled release potential. In this study, we used magnetic resonance microscopy (MRM) to nondestructively and dynamically analyze the water hydration process of xanthan-based tablets. The swelling process was characterized by well-resolved fronts of erosion, swelling, and penetration. The experimental results were complemented by numerical simulations of the polymer matrix hydration process. In the simulations, the polymer tablet matrix was modeled as an assembly of interacting chains with embedded drug particles, while its hydration process was mediated by interaction with solvent particles. The swelling dynamics were modeled within a Monte Carlo-based bond fluctuation model (BFM) that elegantly accounted for steric and nearest-neighbor interactions. This study provides an efficient experimental–theoretical approach for the study of polymer matrix swelling processes.

• Jezik: Angleški jezik
• Ključne besede: drug delivery, polymer matrix hydration, swelling, bond fluctuation model, correlation function
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: FMF - Fakulteta za matematiko in fiziko
• Različica publikacije: Objavljena publikacija
• Datum objave: 01.03.2024
• Leto izida: 2024
• Št. strani: Str. 1-14
• Številčenje: Vol. 16, iss. 5, [article no.] 601
• PID: 20.500.12556/RUL-154597
• UDK: 53
• ISSN pri članku: 2073-4360
• DOI: 10.3390/polym16050601
• COBISS.SI-ID: 186456835
• Datum objave v RUL: 23.02.2024

Gradivo je del revije

• Naslov: Polymers
• Skrajšan naslov: Polymers
• Založnik: MDPI
• ISSN: 2073-4360
• COBISS.SI-ID: 517951257

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: prenos zdravil

Projekti

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P1-0060
• Naslov: Eksperimentalna biofizika kompleksnih sistemov in slikanje v biomedicini