The effect of polymer–solvent interaction on the swelling of polymer matrix tablets: a magnetic resonance microscopy study complemented by bond fluctuation model simulations

Bajd, Franci (author), Mikac, Urška (author), Mohorič, Aleš (author), Serša, Igor (author)

Polymer matrix tablets are an important drug-delivery system widely used for oral drug administration. Understanding the tablet hydration process, both experimentally and theoretically, is, thus, very important for the development of drug delivery systems that exhibit high drug loading capacity and controlled release potential. In this study, we used magnetic resonance microscopy (MRM) to nondestructively and dynamically analyze the water hydration process of xanthan-based tablets. The swelling process was characterized by well-resolved fronts of erosion, swelling, and penetration. The experimental results were complemented by numerical simulations of the polymer matrix hydration process. In the simulations, the polymer tablet matrix was modeled as an assembly of interacting chains with embedded drug particles, while its hydration process was mediated by interaction with solvent particles. The swelling dynamics were modeled within a Monte Carlo-based bond fluctuation model (BFM) that elegantly accounted for steric and nearest-neighbor interactions. This study provides an efficient experimental–theoretical approach for the study of polymer matrix swelling processes.

• Language: English
• Keywords: drug delivery, polymer matrix hydration, swelling, bond fluctuation model, correlation function
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FMF - Faculty of Mathematics and Physics
• Publication version: Version of Record
• Publication date: 01.03.2024
• Year: 2024
• Number of pages: Str. 1-14
• Numbering: Vol. 16, iss. 5, [article no.] 601
• PID: 20.500.12556/RUL-154597
• UDC: 53
• ISSN on article: 2073-4360
• DOI: 10.3390/polym16050601
• COBISS.SI-ID: 186456835
• Publication date in RUL: 23.02.2024

Record is a part of a journal

• Title: Polymers
• Shortened title: Polymers
• Publisher: MDPI
• ISSN: 2073-4360
• COBISS.SI-ID: 517951257

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: prenos zdravil

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P1-0060
• Name: Eksperimentalna biofizika kompleksnih sistemov in slikanje v biomedicini