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Dendritic cell activation and cytokine response in vaccine breakthrough TBE patients after in vitro stimulation with TBEV
ID
Marušić, Miša
(
Avtor
),
ID
Kopitar, Andreja Nataša
(
Avtor
),
ID
Korva, Miša
(
Avtor
),
ID
Knap, Nataša
(
Avtor
),
ID
Bogovič, Petra
(
Avtor
),
ID
Strle, Franc
(
Avtor
),
ID
Ihan, Alojz
(
Avtor
),
ID
Avšič-Županc, Tatjana
(
Avtor
)
PDF - Predstavitvena datoteka,
prenos
(1,03 MB)
MD5: E248AD73A3997B633E0571599B87D465
URL - Izvorni URL, za dostop obiščite
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1190803/full
Galerija slik
Izvleček
Tick-borne encephalitis (TBE) is a viral infection of the human central nervous system caused by the TBE virus (TBEV). The most effective protective measure against TBE is vaccination. Despite the highly immunogenic vaccine, cases of vaccine breakthroughs (VBTs) occur. One of the first targets of infection is dendritic cells (DC), which represent a fundamental bridge between innate and adaptive immunity through antigen presentation, costimulation, and cytokine production. Therefore, we investigated the activation and maturation of DCs and cytokine production after in vitro TBEV stimulation of peripheral blood mononuclear cells (PBMCs) obtained from VBT and unvaccinated TBE patients. Our results showed that the expression of HLA-DR and CD86 on DCs, was upregulated to a similar extent in both vaccinated and unvaccinated TBE patients but differed in cytokine production after stimulation with TBEV. PBMCs from patients with VBT TBE responded with lower levels of IFN-α and the proinflammatory cytokines IL-12 (p70) and IL-15 after 24- and 48-hour in vitro stimulation with TBEV, possibly facilitating viral replication and influencing the development of cell-mediated immunity. On the other hand, significantly higher levels of IL-6 in addition to an observed trend of higher expression of TNF-α measured after 6 days of in vitro stimulation of PBMC could support disruption of the blood–brain barrier and promote viral and immune cell influx into the CNS, leading to more severe disease in VBT TBE patients.
Jezik:
Angleški jezik
Ključne besede:
tick-borne encephalitis
,
vaccine breakthrough
,
cytokines
,
dendritic cells
,
immune response in vitro
Vrsta gradiva:
Članek v reviji
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
MF - Medicinska fakulteta
Status publikacije:
Objavljeno
Različica publikacije:
Objavljena publikacija
Leto izida:
2023
Št. strani:
9 str.
Številčenje:
Vol. 14, art. 1190803
PID:
20.500.12556/RUL-153997
UDK:
616.9
ISSN pri članku:
1664-3224
DOI:
10.3389/fimmu.2023.1190803
COBISS.SI-ID:
152562691
Datum objave v RUL:
18.01.2024
Število ogledov:
472
Število prenosov:
34
Metapodatki:
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Objavi na:
Gradivo je del revije
Naslov:
Frontiers in immunology
Skrajšan naslov:
Front. immunol.
Založnik:
Frontiers Media
ISSN:
1664-3224
COBISS.SI-ID:
30774233
Licence
Licenca:
CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:
http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:
To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Sekundarni jezik
Jezik:
Slovenski jezik
Ključne besede:
klopni encefalitis
,
preboj cepiva
,
citokini
Projekti
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
P3-0083
Naslov:
Odnosi parazitskega obstajanja
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
P3-0296
Naslov:
Bolezni in povzročitelji, ki jih v Sloveniji prenašajo členonožci
Financer:
EC - European Commission
Program financ.:
H2020
Številka projekta:
871029
Naslov:
European Virus Archive GLOBAL
Akronim:
EVA-GLOBAL
Financer:
ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Številka projekta:
I0-0022
Naslov:
Mreža raziskovalnih infrastrukturnih centrov Univerze v Ljubljani (MRIC UL)
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