Static and dynamic fMRI-derived functional connectomes represent largely similar information

Matkovič, Andraž (author), Anticevic, Alan (author), Murray, John D. (author), Repovš, Grega (author)

Functional connectivity (FC) of blood-oxygen-level-dependent (BOLD) fMRI time series can be estimated using methods that differ in sensitivity to the temporal order of time points (static vs. dynamic) and the number of regions considered in estimating a single edge (bivariate vs. multivariate). Previous research suggests that dynamic FC explains variability in FC fluctuations and behavior beyond static FC. Our aim was to systematically compare methods on both dimensions. We compared five FC methods: Pearson’s/full correlation (static, bivariate), lagged correlation (dynamic, bivariate), partial correlation (static, multivariate) and multivariate AR model with and without self-connections (dynamic, multivariate). We compared these methods by (i) assessing similarities between FC matrices, (ii) by comparing node centrality measures, and (iii) by comparing the patterns of brain-behavior associations. Although FC estimates did not differ as a function of sensitivity to temporal order, we observed differences between the multivariate and bivariate FC methods. The dynamic FC estimates were highly correlated with the static FC estimates, especially when comparing group-level FC matrices. Similarly, there were high correlations between the patterns of brain-behavior associations obtained using the dynamic and static FC methods. We conclude that the dynamic FC estimates represent information largely similar to that of the static FC.

• Language: English
• Keywords: functional connectivity, autoregressive model, dynamic functional connectivity, brain-behavior associations, measurement, brain, functional magnetic resonance imaging fMRI, neurosciences, neural networks
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FF - Faculty of Arts
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: Str. 1266–1301
• Numbering: Vol. 7, iss. 4
• PID: 20.500.12556/RUL-153571
• UDC: 159.91:612.82
• ISSN on article: 2472-1751
• DOI: 10.1162/netn_a_00325
• COBISS.SI-ID: 157380355
• Publication date in RUL: 16.01.2024

Record is a part of a journal

• Title: Network neuroscience
• Shortened title: Netw. neurosci.
• Publisher: MIT Press
• ISSN: 2472-1751
• COBISS.SI-ID: 4593096

Licences

• License: CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
• Link: http://creativecommons.org/licenses/by-nc/4.0/
• Description: A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

• Language: Slovenian
• Keywords: funkcijska konektivnost, merjenje, možgani, funkcijsko magnetnoresonančno slikanje fMRI, nevroznanost, nevronske mreže