Intraoperative electrochemotherapy of the posterior resection surface after pancreaticoduodenectomy : preliminary results of a hybrid approach treatment of pancreatic cancer

Čebron, Žan (avtor), Djokić, Mihajlo (avtor), Petrič, Miha (avtor), Čemažar, Maja (avtor), Omerzel, Maša (avtor), Serša, Gregor (avtor), Trotovšek, Blaž (avtor)

Background: Despite extensive research in recent decades, pancreatic cancer continues to be among the most lethal forms of cancer, with no substantial increase in survival rates. Local recurrences account for approximately 30 per cent of all disease recurrences. With the intent to improve survival, we designed a novel, hybrid treatment strategy consisting of surgical resection and additional intraoperative electrochemotherapy of the posterior resection surface. We present the study protocols and preliminary findings of a prospective pilot study investigating this treatment approach. Methods: Consenting patients with resectable pancreatic head ductal adenocarcinoma who met the inclusion criteria were enrolled in the study. After surgical resection, electrochemotherapy with bleomycin was performed using plate electrodes to cover the area between anatomical landmarks. Results: Electrochemotherapy of the posterior resection surface was feasible in all 7 patients. We observed pancreatic fistula grade B in only one patient; all other noted complications were Clavien-Dindo grade 2 or less. The hospital mortality was 0%. Conclusions: Our preliminary results suggest that a hybrid approach combining surgery with intraoperative electrochemotherapy is safe and feasible.

• Jezik: Angleški jezik
• Ključne besede: pancreatic cancer, intraoperative electrochemotherapy, electroporation, pancreaticoduodenectomy, whipple procedure, hybrid treatment, bleomycin
• Vrsta gradiva: Članek v reviji
• Tipologija: 1.01 - Izvirni znanstveni članek
• Organizacija: MF - Medicinska fakulteta ; ZF - Zdravstvena fakulteta
• Status publikacije: Objavljeno
• Različica publikacije: Objavljena publikacija
• Leto izida: 2024
• Št. strani: 7 str.
• Številčenje: Vol. 155, art. 108576
• PID: 20.500.12556/RUL-152883
• UDK: 602.6/.7
• ISSN pri članku: 1567-5394
• DOI: 10.1016/j.bioelechem.2023.108576
• COBISS.SI-ID: 165588227
• Datum objave v RUL: 11.12.2023

Gradivo je del revije

• Naslov: Bioelectrochemistry
• Založnik: Elsevier
• ISSN: 1567-5394
• COBISS.SI-ID: 2502484

Licence

• Licenca: CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
• Povezava: http://creativecommons.org/licenses/by/4.0/deed.sl
• Opis: To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.

Sekundarni jezik

• Jezik: Slovenski jezik
• Ključne besede: rak trebušne slinavke, intraoperativna elektrokemoterapija, elektroporacija

Projekti

• Financer: Drugi - Drug financer ali več financerjev
• Program financ.: University Medical Center Ljubljana, Tertiary research project

• Financer: ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
• Številka projekta: P3-0003
• Naslov: Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev