In Master thesis, we analysed transient heat transfer in bioreactor with capacity of 50 liters, which is used in farmaceutical laboratory for bacterial culture cultivation. Heating and cooling are achieved with double jacket, and when needed, with additional tube baffles also. First, we defined the dimensions of the components according to recommendations. Then, we performed calculation for the process of heating to sterilization temperature followed by cooling to working temperature. We then analyzed critical parameters, where we focused on current variations and input temperatures into the process system. We designed system’s digital twin in program SIMIT, and finally, compared results of analytical and simulative calculation.
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