Your browser does not allow JavaScript!
JavaScript is necessary for the proper functioning of this website. Please enable JavaScript or use a modern browser.
Open Science Slovenia
Open Science
DiKUL
slv
|
eng
Search
Browse
New in RUL
About RUL
In numbers
Help
Sign in
Mechanism and kinetics of CBDA decarboxylation into CBD in hemp
ID
Fućak, Tedi
(
Author
),
ID
Kreft, Samo
(
Author
),
ID
Svedružić, Željko M.
(
Author
),
ID
Tavčar, Eva
(
Author
)
PDF - Presentation file,
Download
(2,56 MB)
MD5: 1DC344F116C6F17CC2F612584A87AC06
URL - Source URL, Visit
https://link.springer.com/article/10.1007/s13562-023-00847-z
Image galllery
Abstract
Cannabidiol (CBD) is a pharmacologically active ingredient for use in medical, cosmetic, and food products. CBD forms from cannabidiolic acid (CBDA) with the process of decarboxylation by heating cannabis (Cannabis sativa L.) material. During the production of CBD-rich material, decarboxylation should be performed in precise conditions regarding temperature and time. The experiments were performed by heating hemp samples at 100, 110, 120, 130, and 140 °C for 180 min. Materials were sampled every 20 min and cannabinoid content was analyzed using HPLC, followed by calculation of kinetic parameters. Experimental results showed an exponential reduction of CBDA in the samples during heating. CBD simultaneously increased, and after a specific point, CBD started degrading. The optimal conditions were 140 °C for 30 min. At the level of molecular orbitals, reaction steps, and reaction coordinates, along with the corresponding changes in molecular energy, the molecular mechanism of CBDA decarboxylation and CBD formation was described. Computational analysis has confirmed that the mechanism of CBDA decarboxylation is a direct beta-keto acid pathway. The course of CBDA decarboxylation depends on the time, temperature, and chemical composition of the sample.
Language:
English
Keywords:
decarboxylation
,
cannabidiolic acid
,
CBDA
,
cannabidiol
,
CBD
,
kinetics
,
cannabis
,
hemp
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2023
Number of pages:
Str. 608–621
Numbering:
Vol. 32, iss. 3
PID:
20.500.12556/RUL-151927
UDC:
582.630:615.3
ISSN on article:
0974-1275
DOI:
10.1007/s13562-023-00847-z
COBISS.SI-ID:
155996419
Publication date in RUL:
25.10.2023
Views:
365
Downloads:
65
Metadata:
Cite this work
Plain text
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Copy citation
Share:
Record is a part of a journal
Title:
Journal of plant biochemistry and biotechnology
Shortened title:
J. plant biochem. biotechnol.
Publisher:
Springer Nature, Society for Plant Biochemistry and Biotechnology
ISSN:
0974-1275
COBISS.SI-ID:
518442265
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
dekarboksilacija
,
kanabidiolna kislina
,
CBDA
,
kanabidiol
,
CBD
,
kinetika
,
konoplja
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P1-0208
Name:
Farmacevtska kemija: načrtovanje, sinteza in vrednotenje učinkovin
Funder:
ARRS - Slovenian Research Agency
Project number:
P4-0127
Name:
Farmacevtska biotehnologija: znanost za zdravje
Similar documents
Similar works from RUL:
Similar works from other Slovenian collections:
Back