Vloga TLR10 v imunskem odzivu pri različnih vrstah sesalcev

Kastelic, Franci (author), Ogorevc, Jernej (mentor)

Tollu-podobni receptorji so pomemben člen imunskega sistema pri sesalcih. V družino TLR spada tudi TLR10. Najdemo ga pri številnih vrstah sesalcev. Izraža se predvsem v tkivih, bogatih z imunskimi celicami, kot so vranica, timus ali pljuča. Ob vezavi ligandov povzroči indukcijo sinteze imunskih modulatorjev citokinov. Gen za TLR10 je med različnimi vrstami sesalcev dobro ohranjen. Raziskave kažejo, da ima receptor imunomodulatorno funkcijo. Primerjava DNA zaporedja gena za TLR10 med različnimi vrstami sesalcev je pokazala, da bolj kot je sorodno zaporedje, bolj podobna je funkcija receptorja. Znanje o ligandih, ki jih TLR10 veže je omejeno. Zaradi dimerizacije s TLR1 in TLR2 se sklepa, da so ligandi podobni ali enaki ligandom teh dveh TLR. Odkrivanje funkcije TLR10 se pogosto izvaja z določanjem povezave med izražanjem receptorja na celicah in količino izločenih citokinov kot so IL-8, IL-17, TNF-α itd. Študije nakazujejo, da se TLR10 aktivira ob okužbah z bakterijami, virusi in tudi glivami. Zaradi odsotnosti izražanja TLR10 v miši je TLR10 najmanj raziskan TLR. Je tudi edini izmed receptorjev te družine, ki lahko deluje tako provnetno kot protivnetno. Zaradi svoje raznolike funkcije je zanimiv za raziskave. Poznavanje delovanja TLR10 bi lahko pomagalo ščititi zdravje ljudi in živali. Ugotovitve nakazujejo tudi na to, da lahko polimorfizmi v zaporedju TLR10 vplivajo na dovzetnost za nekatere bolezni.

• Language: Slovenian
• Keywords: tlr10, citokini, imunski odziv, receptor, sesalci
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Year: 2023
• PID: 20.500.12556/RUL-149775
• COBISS.SI-ID: 164386051
• Publication date in RUL: 10.09.2023

Secondary language

• Language: English
• Title: Role of TLR10 in immune response in different mammalian species

Abstract

Toll-like receptors play a major role in the mammalian immune system. TLR10 is a member of the TLR family and is found in many mammalian species. It is expressed mainly in tissues rich in immune cells, such as the spleen, thymus or lung. The activity of TLR10 is associated with induction of cytokine synthesis. The gene for TLR10 is well conserved among different mammalian species. Reasearch has shown that the receptor has an immunomodulatory function. Comparison of the DNA sequence of the TLR10 gene between different mammalian species has shown that the more closely related the sequence, the more similar the function of the receptor. Knowledge of the TLR10 ligands is limited. Due to dimerisation with TLR1 and TLR2, it is believed that the ligands are similar or identical to the ligands of these two TLRs. The function of TLR10 is often found by determining the relationship between the expression of the receptor on cells and the amount of secreted cytokines such as IL-8, IL-17, TNF-α, etc. Studies suggest that TLR10 is activated in infections with bacteria, viruses and also fungi. Due to the absence of TLR10 expression in mouse, TLR10 is the least studied TLR. It is also the only TLR that can act pro-inflammatory and anti-inflammatory. Its diverse function make it an interesting target for research. Understanding TLR10 function may be of great importance in protecting human and animal health. It is also suggested that polymorphisms in the sequence of TLR10 may influence susceptibility to certain deaseses.

• Keywords: tlr10, cytokines, immune response, receptor, mammals