Sinteza 1,4-dienov iz alil bromida ter terminalnih alkinov

Švajger, Anja (author), Štefane, Bogdan (mentor)

1,4-dieni so sestavljeni iz nekonjugiranega 1,4-dienskega sistema, kjer sta dve nenasičeni dvojni vezi alkena ločena z sp3 hibridiziranim ogljikovim atomom. Imajo širok spekter uporabe, predvsem v medicini. Poleg tega pa se nahajajo v strukturi številnih naravnih snovi, kot so alkakoidi, terpeni, maščobne kisline in poliketidi. V okviru diplomskega dela smo 1,4-diene sintetizirali iz alil bromida in terminalnih alkinov po literaturnem postopku Knochela in Normanta.

• Language: Slovenian
• Keywords: 1, 4-dieni, terminalni alkini, alil bromid, sinteza po Knochelu in Normantu
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2023
• PID: 20.500.12556/RUL-149584
• COBISS.SI-ID: 169861635
• Publication date in RUL: 07.09.2023

Secondary language

• Language: English
• Title: Synthesis of 1,4-dienes from allyl bromide and terminal alkynes

Abstract

1,4-diens are composed out of unconjugated 1,4-dien system in which two unsaturated double bonds of alken are separated with one sp3 hybridised carbon atom. The 1,4-diens have a wide spectrum of usage, mostly in the medical field. Besides that they occur in nature in many substances such as alkaloids, terpens, fatty acids and polyketals. In this thesis 1,4-diens were synthesised from allyl bromide and terminal alkynes according to the procedure described by Knochel and Normant in the literature.

• Keywords: 1, 4-dienes, terminal alkynes, allyl bromide, Knochel and Normant procedure