In my thesis, I studied the conversion of amines with N-trifluoromethylthiosaccharin,
resulting in N-trifluoromethylthio substituted amines. I
tested different amines such as aromatic, heteroaromatic and aliphatic. In the literature, I
found the reaction conditions for the introduction of the SCF3 group into amines and
tested them myself. I first performed the reactions on a smaller scale (0.2 mmol), and in
case of success, also on a larger scale (5 mmol). I purified all products with flash
chromatography, dried them on a rotary evaporator and performed all necessary analyzes
(HRMS, NMR, IR, melting point). I monitored the course of the reactions with TLC. At
the end, I flushed the products with nitrogen, sealed them well and stored them in the
refrigerator.
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