As a part of this Bachelor’s thesis the 6-substituated-4,5-dihydropyridazin-3(2H)-ones 2a and 2b were synthetized using the corresponding γ-keto acids 1a and 1b and hydrazine hydrate (a = Ph, b = Me). Compound 2a was then reduced to 6-phenyltetrahydropyridazin-3(2H)-one (3a). Many different reducing agents were tested but only few of them yielded the desired compound 3a, which was obtained in low yield because of the problems with isolation. Compound 3a can be used in the synthesis of N,N-cyclic azomethine imines via 1,3-dipolar cycloaddition. Compounds 2a and 2b were successfully oxidised to 6-substituated pyridazin-3(2H)-ones 5a and 5b, which are potential reagents in photochemical reactions.
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