Due to the special properties of the fluorine atom interest in fluorine compounds has increased dramatically in medicine, pharmaceuticals and other fields. It can be incorporated into a molecule as a single fluorine atom or as a fluorine-containing functional group. In recent years, scientists have focused in particular on trifluoromethylthiolations – reactions in which the hydrogen atom is substituted by the strongly electrophilic and lipophilic SCF3 group. For such reactions, many nucleophilic and electrophilic reagents have been developed that react with different molecules. The development of nucleophilic reagents started with metal reagents, but over time they have been replaced by less harmful non-metallic reagents such as (Me4N)SCF3. The most commonly used electrophilic reagents are N-SCF3 reagents such as N-trifluoromethylthiosaccharin. It reacts excellently with amines and also with many other functional groups. In many cases, the yields are high.
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