Since their discovery, pyrazolones have become very important for industry, science, and health because of their wide range of utility and easy synthesis. One of their numer-ous effects is antibacterial. A major problem of modern times is the bacterial resistance to antibiotics. For this reason, we decided to synthesize a series of pyrazol-3-ones and test their inhibitory effect on bacterial growth. By varying the substituents at positions 2 and 5, we tested the influence of different groups on the effectiveness of pyrazolones. The syntheses were performed by simple condensation of the corresponding hydrazines and ß-keto esters under mild conditions. The products were purified by column chroma-tography or trituration and the antibacterial effect of the synthesized compounds on 4 bacterial strains was tested by the disk diffusion method.
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