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Uporaba nanodelcev pri zdravljenju raka
ID Zager, Sara (Author), ID Narat, Mojca (Mentor) More about this mentor... This link opens in a new window

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Abstract
Konvencionalne terapije rakavih bolezni, kot so kemo-, radio-, imunoterapija, hormonska terapija in operativna odstranitev so sicer učinkovite, vendar jih zaradi sistemske aplikacije pogosto spremljajo akutni nezaželeni učinki in razvoj odpornosti na zdravila. Nanotehnologija je ena od možnosti, ki nam omogoča, da zmanjšamo pojavnost teh učinkov. Z njo dosežemo tarčno specifično ciljanje rakavih celic, medtem ko na okoliške zdrave celice uporabljeni terapevtski agensi ne učinkujejo. Z različnimi modifikacijami nanodelcev se lahko podaljša čas zadrževanja v tumorskem tkivu, lahko se poveča specifičnost do tumorskih celic, lahko pa se nanodelec modificira na način, da je z različnimi stimulusi sproženo nadzorovano sproščanje zdravilne učinkovine. Z nadaljnjim raziskovanjem tega področja se lahko doseže večja optimizacija nanodelcev, kar lahko v prihodnosti pomeni večjo učinkovitost zdravljenja raka in manjšo verjetnost za povrnitev le-tega.

Language:Slovenian
Keywords:nanodelci, ciljana dostava, protirakave učinkovine, tumorsko mikrookolje
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:BF - Biotechnical Faculty
Year:2023
PID:20.500.12556/RUL-148585 This link opens in a new window
COBISS.SI-ID:162545923 This link opens in a new window
Publication date in RUL:27.08.2023
Views:470
Downloads:47
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Secondary language

Language:English
Title:Use of nanoparticles for cancer treatment
Abstract:
Conventional therapies for cancer diseases, such as chemotherapy, radiotherapy, immunotherapy, hormonal therapy, and surgical removal, are effective, but they often come with acute side effects and the development of drug resistance due to their systemic application. Nanotechnology is one of the options that allows us to reduce the occurrence of these effects. It enables specific targeting of cancer cells, while the therapeutic agents used do not affect the surrounding healthy cells. By using various modifications of nanoparticles, the retention time in tumor tissue can be prolonged, specificity to tumor cells can be increased, and the nanoparticles can be modified to achieve controlled release of the therapeutic agent triggered by different stimuli. Further research in this field can lead to greater optimization of nanoparticles, which may result in higher effectiveness of cancer treatment and a reduced likelihood of its recurrence in the future.

Keywords:nanoparticles, targeted delivery, antitumor drugs, tumor microenvironment

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